This volume of the Urologic Clinics covers the indications, controversies, and complications of Lymphadenectomy in Urologic Oncology. Cancer of the prostate, bladder, testicles, and kidney are covered, along with new imaging modalities and complications of open and minimally invasive lymphadenectomy.

The guest editors, Dr. William Huang and Dr. Ezequiel Becher, have assembled a state-of-the art issue devoted to Advanced and Metastatic Renal Cell Carcinoma (RCC). They have secured expert authors to contribute clinical reviews on the important topics involving treating and managing patients with RCC. Specific articles are devoted to the following topics: Imaging for Metastatic RCC; Adjuvant Therapy for Localized High Risk RCC; Current Standards for Therapeutic Sequencing for Advanced RCC; Role of Lymphadenectomy in patients with advanced RCC; Cytoreductive Nephrectomy in the Era of TKI/IO - Who, When and Why; Minimally Invasive Surgery for Patients with Locally Advanced and Metastatic Disease RCC; Evolving Role of Urologists in the Management of Advanced RCC; Neoadjuvant Therapy for Locally Advanced RCC; Epidemiology and Risk Assessment/Biomarkers for Patients with Advanced RCC; Radiation Therapy for Patients with Metastatic RCC; Evolving Role of Metastatectomy for Patients with Metastatic RCC; and Management of Non-Clear Cell Metastatic RCC. Readers will come away with the information they need to treat and manage patients and to improve outcomes.

In this issue of Urologic Clinics of North America, guest editors Drs. Jeffrey M. Holzbeierlein and Philippe E. Spiess bring their considerable expertise to the topic of Advances in Penile and Testicular Cancer. Top experts in the field provide important clinical updates on the management of penile and scrotal cancer, discuss the current standards of care using evidence-based treatment guidelines, and provide insight on emerging discoveries. This issue provides critical information and updates needed to improve outcomes in patients with diseases that urologists do not see on a daily basis. - Contains 12 relevant, practice-oriented topics, including the psychosocial impact of penile cancer: an unmet need; what is on the horizon in clinical trials for penile and testicular cancer; the use of miRNA to predict teratoma and viable GCT after chemotherapy; testicular cancers survivorship and fertility preservation; and more. - Provides in-depth clinical reviews on advances in penile and testicular cancer, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The past decade has been marked by the acceleration of our understanding of the molecular biology of cancer. Simultaneously, there have been increasing exigencies to diagnose, treat and follow cancer patients more economically. Biomarkers represent the marriage of science and economics. Biomarkers offer the potential to increase the precision of diagnosis, prognosis, and surveillance of urological malignancies. This issue presents the cutting-edge advances of biomarker technology to urologic oncology.

This issue provides much needed updates since Dr. Sheinfeld's issue published in 2007. Dr. Lin has assembled expert authors to provide clinicians with the full breadth of clinical updates on testicular cancer. New to this issue are articles on clinical outcomes, survivorship, and several articles on the management of Nonseminomatous Germ Cell Tumors.

Dr. Samir Taneja, Consulting Editor, is stepping into the Guest Editor role for this issue of Urologic Clinics devoted to Prostate Cancer. He has assembled top experts to address the latest advances in the diagnosis and treatment of prostate cancer. Articles are devoted to the following topics: Whom to Biopsy: Pre-Diagnostic Risk Stratification with Biomarkers, Nomograms, and Risk Calculators; How to Biopsy: Transperineal vs. Tranrectal, Saturation vs. Targeted: What’s the Evidence; Pre-Diagnostic Risk and Assessment with Imaging and Image-guided Biopsy; Whom to treat: Post-Diagnostic Risk Assessment with Gleason score, Risk Models, and Genomic Classifier; Strategies for Staging and Utilization of Imaging; Contemporary Active Surveillance: Candidate Selection, Follow-up Tools, and Expected Outcomes; Focal Ablation of Early Stage Prostate Cancer: Candidate Selection, Treatment Guidance, and Assessment of Outcome; Extent of Lymphadenectomy at Time of Prostatectomy: An Evidence-based Approach; How to Radiate the Prostate: Hypofractionation, Sterotactic Body Radiation Therapy, and Conventional Intensity-Modulated Radiotherapy; Managing Relapse after Surgical Therapy: Adjuvant vs. Salvage Therapy; Newly diagnosed Metastatic Prostate Cancer – Has the Paradigm Changed; Role of Local therapy in Oligometastatic Prostate Cancer: Should we Expect Cure; Approaching the High-Risk Patient; and Castration-Resistant Prostate Cancer: An Algorithmic Approach. Readers will come away with state-of-the-art information on strategies for diagnosing, treating, and managing prostate cancer.

Dr. Samir Taneja is serving as the Guest Editor for this issue that provides updated and technical content on imaging techniques in urology. Top experts provide clinical reviews on the following topics: Dual-Energy Computed Tomography in Genitourinary Imaging; Diffusion-Weighted Genitourinary Imaging; Upper and Lower Tract Urothelial Imaging Using Computed Tomography Urography; Imaging of Solid Renal Masses; Imaging of Cystic Renal Masses; Image-Guided Renal Interventions; Practical Approach to Adrenal Imaging; Technique of Multi-parametric MRI of the prostate; Multi-parametric MRI- Interpretation Including PIRADS v2; Prostate MRI for Staging; Prostate MRI for Post-Treatment Evaluation and Recurrence; Imaging of Prostate Cancer Using 11C-Choline PET/Computed Tomography; Imaging of Prostate Cancer Using Fluciclovine; and Gallium-68 Prostate-Specific Membrane Antigen PET Imaging. Readers will come away with a clearer understanding of how the latest imaging modalities are utilized for disease diagnosis and management.