The First Transcontinental Railroad is stopped dead near its starting point, both in the East and in the West. Repeated injunctions from the president of the “Transcontinental Railroad” are having no effect: His workers are constantly prevented from working by agents of a mysterious traitor. But Lucky Luke witnesses one of the acts of sabotage and stops it. Soon, he is in charge of security for the entire westward push—and he will have his work cut out for him!

Grand Duke Leonid of Russia is in Washington to sign a commercial treaty on behalf of the Tsar. But this larger-than-life aristocrat has read too much Fennimore Cooper and wants to visit the West. The US government is forced to agree to his whim—but wisely chooses Lucky Luke to escort him to the cattle capital of the West: Abilene. A good thing, too, because the Russian Grand Duke encounters real American desperadoes on his visit!

At the end of the Civil War, many former soldiers turn to a life of crime to survive. Joss Jamon and his gang are among the worst of such men. After sacking the town of Los Palitos, they arrange for Lucky Luke to be arrested for their crimes. The lonesome cowboy, a rope already around his neck, is forced to make a deal with the angry citizens: Bring the real bandits back within six months or hang.

Marcel Dalton is the Dalton Brothers’ Swiss uncle. He is not only honest, but a banker to boot. Having purchased a small bank in the US, he decides to hire his nephews to force them to make a honest living. Although he’s assisted by Lucky Luke, they have their work cut out for them. Especially since – as if the ingrained instincts of the four dumbest bandits in the West weren’t enough – there’s also the small matter of the competition: a very unscrupulous banker ...

Gold has been found in the Klondike, a remote region in the Canadian far north! Jasper, the manservant of ‘Tenderfoot’ Waldo, went to try his luck ... and vanished. Worried about his man, Waldo calls upon his old friend Lucky Luke. The two men will have to make the dangerous trip to the Klondike, only to face all those who, in that desolate, inhospitable land, will stop at nothing in order to fleece their fellow man.

Passing through the quiet little town of Rattlesnake, Luke exposes a Mexican gambler as a cheat and runs him out of town. Unfortunately, the hustler ends up in the hands of the Bluefeet Indians and manages to convince them to attack Rattlesnake. A siege begins, during which Luke will have to use all his guile and courage to keep the Bluefeet at bay until the Cavalry arrives.

After a fellow inmate, having received a blow to the head, forgets his own name and is freed as a brand new man, the Daltons start pretending to be amnesiac in order to escape the prison. So as to test their supposed amnesia – and hopefully allow them to retrieve their memories should it be real – they are put in familiar situations: bank hold-ups, train robberies ... under Lucky Luke’s supervision, of course.