This paper discusses opportunities and challenges related to the technical and economic feasibility of developing power generation from geothermal resources at temperatures of 150 degrees C and lower. Insights from projects funded by the U.S. Department of Energy (DOE), Geothermal Technologies Office inform these discussions and provide the basis for some lessons learned to help guide decisions by DOE and the industry in further developing this resource. The technical basis for low-temperature geothermal energy is well established and the systems can be economic today in certain situations. However, these applications are far from a 'plug and play' product; successful development today requires a good knowledge of geothermal system design and operation.