The renaissance of liquid chromatography took place in the late 1960's and early 1970's. The first edition of this book published in 1977 described the detectors that were available at that time and which provided a performance matching that of the contemporary equipment with which they were associated. It is interesting to note that the most popular detectors then (the UV detector, the refractometer detector, the fluorescence detector and the electrical conductivity detector) are still the most commonly used detectors nearly a decade later. Detector design, however, has changed very significantly over the intervening years. Modern high efficiency columns provide very narrow peaks and very fast separations, and thus the physical design of the detectors had to change to meet these new challenges. In 1977, there was little real understanding of the important role played by the detector in the overall function of the chromatographic system and although some of the factors were pointed out in the first edition of this book, in retrospect they appeared to be little understood.This second edition gives an entirely new presentation of the subject of liquid chromatography detectors. It contains sections dealing with the fundamental aspects of the interaction between columns and detectors and the interaction between ancillary equipment and the detector. It brings the reader up-to-date with new designs and novel detecting systems that have been developed since 1977 and extends significantly the subject of the association of the liquid chromatography detector with spectroscopic techniques. In particular the book now explores the association of liquid chromatography with nuclear magnetic resonance, infrared and atomic absorption spectrometry. This book not only gives a comprehensive treatment of the subject of liquid chromatographic detectors and provides a rational procedure for defining their performance and so permit valid comparisons, but also discusses detector performance in relation to the whole of the chromatographic system.

The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.

"Comprehensively covers the design, construction, and operation of gas chromatography, liquid chromatography, and thin-layer chromatography detectors--all in one convenient, up-to-date source. Emphasizes the essential use of common specifications to describe all detectors, allowing easy comparison of their attributes."

Liquid Chromatography Detectors

This book documents the principles of operation, the advantages and drawbacks, and the potential future of currently available liquid chromatographic detectors. In offering a snapshot of the current technology, it provides clear explanations and possible new horizons for both beginners and experts.

This sixth volume in the book series Progress in HPLC-HPCE examines the enhancement of high- performance liquid chromatography through the development of an advanced mode of electrochemical detection (ECD) --- the coulometric array detection --- from its initial, yet problematic, amperometric (thin-layer) design to the highly sensitive, selective and stable coulometric (flow-through) design. Unlike amperometric electrodes, the coulometric electrode is 100% efficient and measures signals from all of the analyte passing through it, which leads to improved sensitivity as well as unique selectivity. The coulometric electrode array offers the resolution of the photodiode array with the extreme sensitivity of an electrochemical detector.

This book documents the principles of operation, the advantages and drawbacks, and the potential future of currently available liquid chromatographic detectors. In offering a snapshot of the current technology, it provides clear explanations and possible new horizons for both beginners and experts.