Details methods for computing valid limits of detection. Clearly explains analytical detection limit theory, thereby mitigating incorrect detection limit concepts, methodologies and results Extensive use of computer simulations that are freely available to readers Curated short-list of important references for limits of detection Videos, screencasts, and animations are provided at an associated website, to enhance understanding Illustrated, with many detailed examples and cogent explanations

For many years in the field of chemical analysis, the concepts of and scientific foundation for the detection limit (DL) and the quantification limit (QL) were in the eyes of the beholder: that is, there was no established consensus on how to compute DL and QL for a given analytical method. Then, in 1968 (and reiterated in 1999), Lloyd Currie of the National Bureau of Standards, later renamed the National Institute of Standards and Technology, published what has become the internationally accepted scientific basis for both concepts. Currie uses statistical hypothesis theory to determine the DL, the methods critical value, and the QL of a completely specified measurement system in analytical chemistry. Curries methodology has been adopted internationally by the International Union of Pure and Applied Chemistry (IUPAC) and by the International Organization for Standardization (ISO), among other international consensus standards bodies. ASTM International, however, has not yet developed a unified DL standard for the general measurement community. ASTM Committee D22 on Air Quality recently developed a draft standard practice for DL in air-quality measurements, which is based on the Currie method. Once finalized, this standard should ensure that DL computations for air measurements using ASTM standards are consistent with those made worldwide using the IUPAC and ISO standard DL methods.

For decades gas chromatography has been and will remain an irreplaceable analytical technique in many research areas for both quantitative analysis and qualitative characterization/identification, which is still supplementary with HPLC. This book highlights a few areas where significant advances have been reported recently and/or a revisit of basic concepts is deserved. It provides an overview of instrumental developments, frontline and modern research as well as practical industrial applications. The topics include GC-based metabolomics in biomedical, plant and microbial research, natural products as well as characterization of aging of synthetic materials and industrial monitoring, which are contributions of several experts from different disciplines. It also contains best hand-on practices of sample preparation (derivatization) and data processing in daily research. This book is recommended to both basic and experienced researchers in gas chromatography.

Selection of the HPLC Method in Chemical Analysis serves as a practical guide to users of high-performance liquid chromatography and provides criteria for method selection, development, and validation. High-performance liquid chromatography (HPLC) is the most common analytical technique currently practiced in chemistry. However, the process of finding the appropriate information for a particular analytical project requires significant effort and pre-existent knowledge in the field. Further, sorting through the wealth of published data and literature takes both time and effort away from the critical aspects of HPLC method selection. For the first time, a systematic approach for sorting through the available information and reviewing critically the up-to-date progress in HPLC for selecting a specific analysis is available in a single book. Selection of the HPLC Method in Chemical Analysis is an inclusive go-to reference for HPLC method selection, development, and validation. Addresses the various aspects of practice and instrumentation needed to obtain reliable HPLC analysis results Leads researchers to the best choice of an HPLC method from the overabundance of information existent in the field Provides criteria for HPLC method selection, development, and validation Authored by world-renowned HPLC experts who have more than 60 years of combined experience in the field

Presents the first comprehensive collection of articles on the fundamentals and applications of a wide variety of chemical sensors. Discusses a range of topics from the development of new sensor concepts to improvement in sensors that have been mass produced for several years. Specific types of sensors discussed include oxygen, electrochemical, microbial, drug, and glucose sensors.

Covering all aspects of transport phenomena on the nano- and micro-scale, this encyclopedia features over 750 entries in three alphabetically-arranged volumes including the most up-to-date research, insights, and applied techniques across all areas. Coverage includes electrical double-layers, optofluidics, DNC lab-on-a-chip, nanosensors, and more.

Paper-Based Analytical Devices for Chemical Analysis and Diagnostics is a valuable source of information for those interested in microfluidics, bioanalytical devices, chemical instrumentation/mechanization, in-field analysis, and more. This book provides a critical review of the scientific and technological progress of paper-based devices, as well as future trends in the field of portable paper-based sensors for chemical analysis and diagnostics directly at point of need. It uniquely focuses on the analytical techniques associated with each type of device, providing a practical framework for any researcher to use while learning how to use new types of devices in their work, deciding which ones are best for their needs, developing new devices, or working toward commercialization. Reviews the evolution of this area and offers predictions for the future of the field of paper-based analytical devices Explores the analytical techniques used in development of paper-based devices Discusses challenges and shortcomings specific to each type of device, helping users and developers to avoid pitfalls