For many years in the field of chemical analysis, the concepts of and scientific foundation for the detection limit (DL) and the quantification limit (QL) were in the eyes of the beholder: that is, there was no established consensus on how to compute DL and QL for a given analytical method. Then, in 1968 (and reiterated in 1999), Lloyd Currie of the National Bureau of Standards, later renamed the National Institute of Standards and Technology, published what has become the internationally accepted scientific basis for both concepts. Currie uses statistical hypothesis theory to determine the DL, the methods critical value, and the QL of a completely specified measurement system in analytical chemistry. Curries methodology has been adopted internationally by the International Union of Pure and Applied Chemistry (IUPAC) and by the International Organization for Standardization (ISO), among other international consensus standards bodies. ASTM International, however, has not yet developed a unified DL standard for the general measurement community. ASTM Committee D22 on Air Quality recently developed a draft standard practice for DL in air-quality measurements, which is based on the Currie method. Once finalized, this standard should ensure that DL computations for air measurements using ASTM standards are consistent with those made worldwide using the IUPAC and ISO standard DL methods.

Details methods for computing valid limits of detection. Clearly explains analytical detection limit theory, thereby mitigating incorrect detection limit concepts, methodologies and results Extensive use of computer simulations that are freely available to readers Curated short-list of important references for limits of detection Videos, screencasts, and animations are provided at an associated website, to enhance understanding Illustrated, with many detailed examples and cogent explanations

Details methods for computing valid limits of detection. Clearly explains analytical detection limit theory, thereby mitigating incorrect detection limit concepts, methodologies and results Extensive use of computer simulations that are freely available to readers Curated short-list of important references for limits of detection Videos, screencasts, and animations are provided at an associated website, to enhance understanding Illustrated, with many detailed examples and cogent explanations

Kontaminationen so früh wie möglich erkennen und damit so früh wie möglich beseitigen: Statistische Methoden, die diesem Ziel dienen, werden hier vorgestellt. Die besprochenen Strategien zum Nachweis und zur Quantifizierung von Schadstoffen lassen sich auf alle Umweltkompartimente anwenden. Praktische Details werden anhand von Fallstudien anschaulich erläutert.

Clinical chemical data are used in many ways in the prevention, diagnosis and treatent of disease. It is obviously essential that the properties measured in the clinic and the results communicated from the laboratory to the clinician are correctly understood. The new Silver Book contains internationally accepted conventions in terminology and nomenclature in clinical chemistry, and is the key to clarity and precision in communication in the discipline

For decades gas chromatography has been and will remain an irreplaceable analytical technique in many research areas for both quantitative analysis and qualitative characterization/identification, which is still supplementary with HPLC. This book highlights a few areas where significant advances have been reported recently and/or a revisit of basic concepts is deserved. It provides an overview of instrumental developments, frontline and modern research as well as practical industrial applications. The topics include GC-based metabolomics in biomedical, plant and microbial research, natural products as well as characterization of aging of synthetic materials and industrial monitoring, which are contributions of several experts from different disciplines. It also contains best hand-on practices of sample preparation (derivatization) and data processing in daily research. This book is recommended to both basic and experienced researchers in gas chromatography.