Book includes a CD-ROM. This book provides foundational information on modeling light propagation through diffusive media, with special emphasis on biological tissue. A summary of the theoretical background on light propagation through diffusive media is provided with the aid of easy-to-use software designed to calculate the solutions of the diffusion equation. The book also provides: The basic theory of photon transport with the analytical solutions of the diffusion equation for several geometries Detailed coverage of the radiative transfer equation and the diffusion equation The theories and the formulae based on the diffusion equation that have been widely used for biomedical applications The general concepts and the physical quantities necessary to describe light propagation through absorbing and scattering media A description of the software provided on the CD-ROM, along with the accuracy of the presented solutions. Although the theoretical and computational tools provided with this book and CD-ROM have their primary use in the field of biomedical optics, there are many other applications in which they can be used, including agricultural products, forest products, food products, plastic materials, pharmaceutical products, and many others.

This second edition is completely revised and improved and contains eight new chapters and six new appendixes. In addition to the theoretical background on light propagation through diffusive media, this update also provides new didactical material, including: • A comprehensive statistical approach to the photon penetration depth in diffusive media • An introduction to anomalous transport • An anisotropic transport approach within the framework of diffusion theory • An introduction to the invariance properties of radiative transfer in non-absorbing media • A heuristic explanation of ballistic photon propagation • An expanded description of core Monte Carlo simulation methods • A series of new analytical solutions of the diffusion equation for new geometries • Some original solutions in the time domain of the diffusion equation in the presence of Raman and fluorescence interactions • New MATLAB® codes of the presented solutions • A revised and enlarged set of numerical Monte Carlo results for verification of the presented solutions • An augmented bibliography covering the field of tissue optics. Although the theoretical and computational tools provided in this book have their primary use in the field of biomedical optics, there are many other applications in which they can be used, including, for example, analysis of agricultural products, study of forest canopies or clouds, and quality control of industrial food, plastic materials, or pharmaceutical products, among many others.

This text begins by describing the basic principles and diagnostic applications of optical techniques based on detecting and processing the scattering, fluorescence, FT IR, and Raman spectroscopic signals from various tissues, with an emphasis on blood, epithelial tissues, and human skin. The second half of the volume discusses specific imaging technologies, such as Doppler, laser speckle, optical coherence tomography (OCT), and fluorescence and photoacoustic imaging.

The main idea behind this book is to present a rigorous derivation of the equations that govern light propagation in highly scattering media, with an emphasis on their applications in imaging in biology and medicine. The equations and formulas for diffuse light propagation are derived from the very beginning, and all the necessary analytical expressions needed to complete a complex imaging or characterization problem are presented step by step.This book provides postgraduate and PhD students with the basic framework and sufficient knowledge in light transport and the related mathematical methods to solve most complex problems that may appear in biomedical applications involving multiple scattered light. All results presented are formal analytical derivations from the complete problem, presenting, in those cases which are relevant, approximations to these expressions.

Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.

This volume comprises chapters on the cutting-edge research in photonics undertaken at IIT Kanpur. Photonics requires scientists and engineers to work closely together in addressing challenges which are interdisciplinary in nature. At IIT Kanpur, research is being pursued in several key areas of photonics namely fiber-optics, nanophotonics, quantum optics, optical spectroscopy and imaging, biophotonics, and photonic devices. This volume brings together contributions from experts to obtain a contemporary perspective in photonics research. The reader will find articles about coherent optical communications, novel photonic nanostructures, nano-structured materials for light control, optical tweezers with nanoscale applications, quantum coherence and entanglement, photodiode arrays and quantum metrology. The volume also includes chapters on cancer diagnostics with optical tomography, protein fluctuations at microsecond scale at single-molecule level, and visualization of motion in a droplet which are interdisciplinary in nature. The contents of this book will be of use to researchers, students, and professionals working across all domains of photonics.