Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.

Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

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There are three fundamental issues in the field of screen translation, namely, the relationship between verbal output and pictures and soundtrack, between a foreign language/culture and the target language/culture, and finally between the spoken code and the written one. All three issues are raised and discussed by contributors to this special issue of The Translator. The topics covered include the following: the use of multimodal transcription for the analysis of audiovisual data; the depiction and reception of cultural otherness in Disney animated films produced in the 1990's; the way in which subtitles in Flanders strengthen the already streamlined narratives of mainstream film stories, and how they 'enhance' the characteristics of the films and their underlying ideology; developing a research methodology for testing the effectiveness of intralingual subtitling for the deaf and hard of hearing; the pragmatic, semiotic and communicative dimensions of puns and plays on words in The Simpsons; the reception of translated humour in the Marx Brothers' film Duck Soup; and non-professional interpreting in live interviews on breakfast television in Finland. The volume also includes a detailed profile of two postgraduate courses that have been successfully piloted and run at the Universitat Autònoma de Barcelona: the Postgrado de Traducción Audiovisual and the Postgrado de Traducción Audiovisual On-line.

The SPELIT POWER MATRIX is a leadership tool for untangling the organizational environment from a social, political, economic, legal, intercultural and technical view. The SPELIT analysis method was developed for adult learners to have a framework for determining and formulating the answer to the question: What is? There is a need to analyze the environment in all organizations, whether you are entering a new organization or to benchmark the existing organization. The purpose of this text is to show how perceptive leaders can analyze environments in preparation for possible future action. We demonstrate how the methodology aligns with previous theories regarding environmental scanning and produces a workable framework for the perceptive leader. The SPELIT POWER MATRIX is intended for practitioners doing a market analysis or diagnosis prior to implementing transitions, benchmarking in anticipation of an intervention, and can be used by undergraduate students and seasoned practitioners.

This handbook explores the rapid growth in childhood developmental disabilities (DD) treatments. It reviews current evidence-based treatments for common psychopathologies and developmental disorders and evaluates the strengths of the treatments based on empirical evidence. Spanning infancy through the transition to young adulthood, chapters provide definitions, etiologies, prevalence, typical presentation and variants, assessment and diagnostic information, and age considerations. Chapters also review established and emerging psychological approaches and pharmacotherapies for cognitive, behavioral, emotional, medical, academic, and developmental issues as diverse as mood disorders, the autism spectrum, memory problems, feeding disorders, Tourette syndrome, and migraines. The wide range of topics covered aids practitioners in working with the complexities of young clients’ cases while encouraging further advances in an increasingly relevant field. Topics featured in this handbook include: An introduction to Applied Behavior Analysis. Parent training interventions. Treatment strategies for depression in youth. Assessment and treatment of self-injurious behaviors in children with DD. Treatment approaches to aggression and tantrums in children with DD. Interventions for children with eating and feeding disorders. The Handbook of Childhood Psychopathology and Developmental Disabilities Treatment is a must-have resource for researchers, graduate students, clinicians, and related therapists and professionals in clinical child and school psychology, pediatrics, social work, developmental psychology, behavioral therapy/rehabilitation, child and adolescent psychiatry, and special education.