ACPs journal, Annals of Internal Medicine, is one of the most prestigious journals in medicine. This new book looks at the landmark papers published in Annals, as selected by leading experts from each subspecialty of internal medicine, and how they impacted (and continue to influence) medical science.

50 Studies Every Internist Should Know presents key studies that shape today's practice of internal medicine. Selected using a rigorous methodology, the studies cover topics including: preventative medicine, endocrinology, hematology and oncology, musculoskeletal diseases, nephrology, gastroenterology, infectious diseases, cardiology, pulmonology, geriatrics and palliative care, and mental health. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This book is a must-read for health care professionals and anyone who wants to learn more about the data behind clinical practice.

Landmark Papers in General Surgery will give surgeons, surgical trainees and other healthcare professionals an expert appraisal of key papers, and fast access to the evidence base behind current clinical practice in General Surgery. Each chapter draws together a fascinating selection of the most important clinical trials across every subspecialty within General Surgery, as selected and appraised by a panel of experts. Organized according to a common format, each discussion offers a clear structure by which to appraise the medical literature. Following a background summary of each trial, experts discuss the impact of the research and critique the methods used, giving the reader rapid understanding of the paper's place within the wider field of research. This emphasis on the tools of critical appraisal is enhanced by an introductory chapter equipping the reader with the skills required to knowledgeably appraise a research paper. For clinicians needing to keep abreast of the vast scope of medical research, this book will prove an interesting and timesaving resource, but it will also appeal to allied health professionals keen to improve the depth of their understanding of surgery. By bringing together the evidence base with expert guidance on critical appraisal, higher surgical trainees preparing for the academic and specialty sections of the FRCS exit examination will also find the text invaluable as a means of consolidating and nuancing their knowledge.

This book identifies the key scientific articles in the field of Intensive Care and explains why these papers are important in contemporary clinical management. Identifying those influential contributors who have shaped the practice of modern Intensive care practice, the book includes commentaries on 50 seminal papers in a wide range of areas. enal This an invaluable reference for trainees, fellows, and surgeons studying for exams, as well as for seasoned surgeons and physicians who want to stay current in their field.

This book describes the evolution of treatment in oncology through the lens of approximately 250 landmark clinical trials. The well-designed clinical trial is essential to the practice of medicine. There is no field that has embraced or been transformed more by the clinical trial than oncology. Each primary cancer site has a remarkable story that can be told through clinical trials. For example, patients who presented decades ago with soft tissue sarcoma of the extremities would invariably undergo limb amputation. The landmark National Cancer Institute study by Rosenberg et al. randomized patients to limb sparing surgery followed by adjuvant radiation therapy compared with limb amputation. This study helped change the standard of care by allowing most patients to retain their functioning limbs with an improvement in quality of life and no compromise in overall survival. Such major clinical trials for common malignancies including breast, prostate, lung, gastrointestinal, genitourinary, and gynecologic cancers are discussed. Because oncology is multidisciplinary, this book should be of interest for radiation oncologists, surgeons, medical oncologists, and other physicians interested in learning more about the landmark trials that have shaped oncology.

Landmark Papers in Cardiovascular Medicine provides a thorough and wide-ranging analysis of core examples of novel research, clinical trials and seminal papers that have paved the way for breakthroughs in the management of the entire spectrum of cardiovascular disease.