We are very pleased to put forth the first edition of 'Laboratory Manual of Physical Pharmaceutics II'. This manual is prepared as per PCI Education Regulations, 2014 for Degree Course in Pharmacy. This manual is designed for 'outcome-based education' and each experiment is arranged in a uniform way such as practical significance, practical outcomes (PrOs) and its mapping with course outcomes, minimum theoretical background, resources used, procedure, precautions, observations, result, conclusion, references and related questions. A sincere attempt has been made through this manual to provide practical knowledge to the students related to various experiments in Physical Pharmaceutics II. The manual mainly includes the experiments through which the students will learn how the basic properties of drug like solubility, dissolution, can limit the bioavailability of drug and in turn the efficacy of the drug. The solubility enhancement techniques like reduction of particle size, use of solubilizing agents or prodrugs etc. are also discussed. The students will also learn about the importance of drug stability and how the parameters like temperature, pH, humidity and light can affect the drug stability. Physical pharmaceutics is very important subject which helps the researchers to design and formulate various dosage forms including its manufacturing aspects. The students will be proficient in handling various equipment used in physical pharmaceutics laboratory. The students will also be able to determine pKa, partition coefficient, surface tension, critical micelle concentration, HLB value, stability constant, buffer capacity, etc. in the laboratory. We have taken extra efforts to make the experiments simpler, easy to understand and perform. The graphs have also been provided wherever necessary. Each experiment is divided into sections like aim, practical significance, relevant course outcomes, practical skills, relevant affective domain related outcomes, practical outcomes, minimum theoretical background, requirements, related questions, and references. The manual has been designed with more emphasis on the practical skill improvement of the students so that the students can perform the practical with ease and comfort. We are very much thankful to the designer, publisher, printers and all the stakeholders for putting their efforts for successfully bringing this manual out for the students. Hope this manual will help the students to learn the concept, principles and perform the experiments. We wish them all the best!!!

It was suggested by many teachers engaged in the field of Pharmacy that there is a need for Laboratory manual of physical pharmacy as it is the fundamental course of basic pharmaceutics and Pharmaceutical Analysis.

We are very pleased to put forth the first edition of 'Laboratory Manual of Physical Pharmaceutics I'. This manual is prepared as per PCI Education Regulations, 2014 for Degree Course in Pharmacy. This manual is designed for 'outcome-based education' and each experiment is arranged in a uniform way such as practical significance, practical outcomes (PrOs) and its mapping with course outcomes, minimum theoretical background, resources used, procedure, precautions, observations, result, conclusion, references and related questions. A sincere attempt has been made through this manual to provide practical knowledge to the students related to various experiments in Physical Pharmaceutics I. The manual mainly includes the experiments through which the students will learn how the basic properties of drug like solubility, dissolution, can limit the bioavailability of drug and in turn the efficacy of the drug. The solubility enhancement techniques like reduction of particle size, use of solubilizing agents or prodrugs etc. are also discussed. The students will also learn about the importance of drug stability and how the parameters like temperature, pH, humidity and light can affect the drug stability. Physical pharmaceutics is very important subject which helps the researchers to design and formulate various dosage forms including its manufacturing aspects. The students will be proficient in handling various equipment used in physical pharmaceutics laboratory. The students will also be able to determine pKa, partition coefficient, surface tension, critical micelle concentration, HLB value, stability constant, buffer capacity, etc. in the laboratory. We have taken extra efforts to make the experiments simpler, easy to understand and perform. The graphs have also been provided wherever necessary. Each experiment is divided into sections like aim, practical significance, relevant course outcomes, practical skills, relevant affective domain related outcomes, practical outcomes, minimum theoretical background, requirements, related questions, and references. The manual has been designed with more emphasis on the practical skill improvement of the students so that the students can perform the practical with ease and comfort. We are very much thankful to the designer, publisher, printers and all the stakeholders for putting their efforts for successfully bringing this manual out for the students. Hope this manual will help the students to learn the concept, principles and perform the experiments. We wish them all the best!!!

A Laboratory Manual of Physical Pharmaceutics is introduced to the B.Pharm students for easy understanding of the principles of physical pharmaceutics. The Experimental manual covers experiments to provide fundamental principles of physical pharmacy necessary to design physically and chemically stable dosage forms and ensure their therapeutic safety and efficacy. This manual is a unique in nature as it covers the two necessities of students: text on theoretical principles and its application including illustrative exercises in the form of practical. This Book illustrates all the experiments included in various Universities syllabus of physical pharmacy. - It also provides an integrated understanding of theory and practical applications associated with physicochemical concepts in a very lucid language. Reviews the physico-chemical concepts in the design of various dosage forms. - Provides several experiments related to physical chemical characteristics of any dosage forms. - Useful to teachers also

This book is an invaluable source designed to meet the needs of pharm.D and other pharmacy courses. This book was made according to the PCI syllabus. This book covers topics like syrups, elixirs, linctus, solutions, liniments, suspensions, emulsions, powders, suppositories, incompatibilities, with an introduction before it. This book helps the student to write the academic pharmaceutics record more easily. It has been noticed that practical of pharmaceutics leave students a little confused, especially during their examination. Finally, this book aims to present the practicals in a student friendly style so that they can easily grasp and do the practicals in the lab more easily by own which interns will help them to achieve the best grades in examinations.

1 Surface and Interface phenomenon 2 Rheology 3 Chemical Kinetics and Stability 4 Micromeritics 5 Colloids