First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

`The book is important for those involved in aquaculture and those wishing to learn more about the effects of non-infectious disorders and the mechanisms of response within fish and is thoroughly recommended.' Journal of Fish Diseases --

Do your kids love to color? Then this is the activity book you've been looking for! Created by a former preschool teacher and grandfather of 8 children, our coloring and activity book was designed for boys and girls aged 2 to 6 years old. Spend a colorful, funfilled time with your kids or grandkids, or let them enjoy it by themselves. Helps You Teach Your Child: - The Alphabet from A-Z. - How to Write the Letters in Uppercase and Lowercase. - How to Count from 1 to 10. - How to Write Numbers. - How to Spell the Numbers. Activities such as coloring will improve your child's pencil grip, as well as helping them to relax and develop their imagination. SPECIAL BONUS #1: Includes extra pages to color, extra pages to write out the big and little letters, as well as extra pages for writing and spelling numbers. SPECIAL BONUS #2: Includes the lyrics to 4 nursery rhymes to start your own sing-a-longs with your child or grandchild! No more trying to figure out how to help your kids learn their ABCs and 123s - it's all here! You'll both love Now I Know My ABCs & 123s Coloring and Activity Book! Makes Learning for Kids Fun! - The Personalized cover makes it their coloring book! - Each letter of the alphabet has its own page with a simple drawing your child can color. - Age-appropriate images for pre-school and children under 6 years old. - Dedicated pages for learning to write upper and lowercase letters. - Helps you teach your child to count from 1-10. - Dedicated pages for writing and learning how to spell numbers. - A nice, large format for small hands to enjoy (8.5"x 11", 128 pages) - Includes the words to Twinkle Twinkle Little Star, This Old Man, B-I-N-G-O, and Mary Had a Little Lamb. Order one for your child or grandchild today!

A hilarious and heartfelt illustrated memoir of living with specific learning difficulties. In Everything is Going to be K.O., Kaiya Stone writes about her experiences of living with specific learning difficulties: from struggling at school, to being diagnosed with dyslexia and dyspraxia at university, and performing her own one-woman stand up show inspired by her journey. Always funny and unfailingly honest, Kaiya not only outlines the frustrations of having SpLDs, but also the ways in which they have fuelled her creativity. She calls for neurodiversity to be celebrated so that instead of questioning how we are 'supposed' to think, we instead take pride in our cognitive differences. Everything is Going to be K.O. is for anyone who knows, or has wondered, what it is like to live with learning difficulties today.

This volume is based on the Proceedings of the International Conference on "Microbial Infections: Role of Biological Response Modifiers" held in Tampa, FL, May 29-31, 1991. The major purpose of this conference was to bring together in one forum prominent investigators from around the world studying a variety of microbial pathogens, including bacteria, viruses, and fungi, and the effects of biological response modifiers (BRM) on the immune response to these microorganisms. BRM have been widely utilized in the area of antitumor resistance and include not only experimental tumor cell vaccines, but also biologically active substances such as cytokines, i. e. , interferons, tumor necrosis factor, and interleukins, as well as products from bacteria which influence host resistance mechanisms. It is the belief of the organizers of this Conference that it was very timely to discuss in detail BRMs as they impact on microbial infections per se. It is now widely accepted that immunocompromised individuals, including those exposed to immunosuppressive substances such as antimetabolites used for chemothera py of malignancies, or infectious agents, such as the human immunodeficiency virus and other viruses which depress the immune response and, in turn, affect a host so as to become highly susceptible to opportunistic microorganisms, benefit from BRM stimulation of their immune system. A wide variety of immunomodulators are now being studied in terms of treating infectious diseases, as well as malignancy and autoimmune diseases.

This book has been made possible by the contributions of leading scientists and clinicians from upcoming and interdisciplinary fields of research concerning the molecular and clinical features of insulin resistance. Multiple metabolic disturbances associated with Insulin Resistance include inflammatory cytokines, adipokines, endothelial dysfunction, tissue-specific defects in insulin action and signaling, oxidative stress, ectopic lipid deposition, and disordered neuroregulation. This book aims to encourage scientists and physicians - working separately on various aspects of Insulin resistance and metabolic syndrome for early detection of the first signs indicating the onset of a metabolic misbalance in order to prevent the consecutive cascades which lead to metabolic syndrome, resulting in the so-called diseases of modern civilization - cancer, diabetes and hypertension.