Clinical Trials in Oncology, Third Edition
Title | Clinical Trials in Oncology, Third Edition PDF eBook |
Author | Stephanie Green |
Publisher | CRC Press |
Pages | 266 |
Release | 2012-05-09 |
Genre | Mathematics |
ISBN | 1439814481 |
The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data. Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.
Tropical Diseases Bulletin
Title | Tropical Diseases Bulletin PDF eBook |
Author | |
Publisher | |
Pages | 584 |
Release | 1918 |
Genre | Medicine |
ISBN |
Theory at a Glance
Title | Theory at a Glance PDF eBook |
Author | Karen Glanz |
Publisher | |
Pages | 52 |
Release | 1997 |
Genre | Health behavior |
ISBN |
A National Cancer Clinical Trials System for the 21st Century
Title | A National Cancer Clinical Trials System for the 21st Century PDF eBook |
Author | Institute of Medicine |
Publisher | National Academies Press |
Pages | 317 |
Release | 2010-07-08 |
Genre | Medical |
ISBN | 0309157870 |
The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.
Implementation Science at a Glance
Title | Implementation Science at a Glance PDF eBook |
Author | National Cancer Institute (U.S.) |
Publisher | Government Printing Office |
Pages | 47 |
Release | 2019-04-01 |
Genre | Medical |
ISBN | 0160950694 |
While many effective interventions can reduce cancer risk, incidence, and death, as well as enhance quality of life, they are of no benefit if they cannot be delivered to those in need. In the face of increasingly dynamic and resource-constrained conditions, implementation science plays a critical role in delivering cancer control practices. This 30-page workbook was written by members of the NCI (National Cancer Institute) implementation Science team and reviewed by nearly 100 public health practitioners and implementation science researchers. Through summaries of key theories, methods, and models, the guide shows how greater use of implementation science can support the effective adoption of evidence-based interventions. Case studies illustrate how practitioners are successfully applying implementation science in their cancer control programs
Anticancer Drug Development Guide
Title | Anticancer Drug Development Guide PDF eBook |
Author | Beverly A. Teicher |
Publisher | Springer Science & Business Media |
Pages | 514 |
Release | 2004-02-01 |
Genre | Medical |
ISBN | 1592597394 |
This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Reducing Environmental Cancer Risk
Title | Reducing Environmental Cancer Risk PDF eBook |
Author | Suzanne H. Reuben |
Publisher | DIANE Publishing |
Pages | 240 |
Release | 2010-10 |
Genre | Health & Fitness |
ISBN | 1437934218 |
Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.