Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

The spectrum of addiction disorders presents practitioners with numerous challenges—among them the widening gap between a growing evidence base and the translation of this knowledge into treatment outcomes. Addiction Medicine addresses this disconnect, clearly explaining the role of brain function in drug taking and other habit-forming behaviors, and applying this biobehavioral framework to the delivery of evidence-based treatment. Its state-of-the-art coverage provides clinically relevant details on not only traditional sources of addiction such as cocaine, opiates, and alcohol, but also more recently recognized substances of abuse (e.g., steroids, inhalants) as well as behavioral addictions (e.g., binge eating, compulsive gambling, hoarding). Current behavioral and medical therapies are discussed in depth, and the book’s close attention to social context gives readers an added lens for personalizing treatment. An international panel of expert contributors offers the most up-to-date information on: Diagnosis and classification Neurobiological and molecular theories of addiction Behavioral concepts of addiction Clinical aspects of addiction to a wide range of substances, including opiates, stimulants, sedatives, hallucinogens, alcohol, nicotine, and caffeine Science-based treatment options: pharmacotherapy, pharmacogenetics, potential vaccines, brief and compliance-enhancing interventions, cognitive behavioral treatment, behavioral management, and other psychosocial interventions Behavioral addictions—including compulsive eating, Internet messaging, and hypersexuality—and their treatment Addiction in specific populations, including adolescents, the elderly, pregnant women, and health care professionals Legal, disability, and rehabilitation issues At once comprehensive and integrative, Addiction Medicine is an essential text and a practice-expanding tool for psychiatrists, health psychologists, pharmacologists, social workers, drug counselors, trainees, and general physicians/family practitioners.

This book provides an extensive, up-to-date overview of the ways in which information and communication technologies (ICTs) can be used to develop tourism and hospitality. The coverage encompasses a wide variety of topics within the field, including virtual reality, sharing economy and peer-to-peer accommodation, social media use, hotel technology, big data, robotics, and recommendation systems, to name but a few. The content is based on the 2019 ENTER eTourism conference, organized in Nicosia, Cyprus by the International Federation for Information Technologies and Travel & Tourism (IFITT) – the leading independent global community for the discussion, exchange, and development of knowledge on the use and impact of new ICTs in the travel and tourism industry. The book offers a global perspective and rich source of information on important innovations and novel ideas. Though it will prove especially valuable for academics working in the eTourism field, it will also be of considerable interest to practitioners and students.

Design.

Gerald of Wales was an ecclesiastic, a servant and critic of the Angevin kings, and a prolific and vitriolic writer. Born in Pembrokeshire of mixed Norman and Welsh blood in the middle years of the twelfth century, he was appointed archdeacon of Brecon in 1175, but that was the highest officehe attained, despite his indefatigable efforts in the years 1198-1203 to become not merely bishop, but archbishop, of St Davids. His death was reported in 1223. His Instruction for a Ruler (De principis instructione) is of interest for three main reasons: it provides a detailed and violentlypartisan account of the last days of Henry II of England; it is full of miscellaneous but valuable stories and anecdotes (such as the account of the discovery of the tomb of Arthur and Guinevere, and the legend of the destruction of the Picts); and it is a monument to the literary culture of ahighly educated writer at the heart of the twelfth-century Renaissance.