TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com.

Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pharmaceuticals and much more. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology. - New chapters covering important and timely topics such as melamine and cyanuric acid, toxicogenomics, toxic gases and veterinary medical geology - Expanded look at international topics, such as epidemiology of animal poisonings, regulatory guidelines and poisonous plants in Europe - Heavily contributed book with chapters written by qualified and well-experienced authorities across all areas of veterinary toxicology - Problem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology

Organized around real patient scenarios, Clinical Review of Oral and Maxillofacial Surgery: A Case-based Approach, 2nd Edition, covers all the material you need to know for the board, in-service, and certification exams, while also preparing you to handle common patient situations in professional practice. Over 100 teaching cases are brought to life with an overview of the most common clinical presentations, physical examination findings, diagnostic tools, complications, treatments, and discussions of possible issues. This text covers the full scope of modern oral and maxillofacial surgery, while helping you focus on the conditions and disorders which are the most common, or have significant implications for modern clinical practice. "I would most definitely recommend this book." Reviewed by: N.Galligan, British Dental Journal Date: Jan 2015 Case-based approach incorporates teaching around real patient scenarios to actively engage and raise your interest and retention of the information. 103 cases, many of which are new, represent the full scope of modern oral and maxillofacial surgery practice to encompass the most common and significant implications for modern clinical practice, including content emphasized on OMS boards and training exams. Detailed illustrations including one or more radiographs, full-color clinical photographs, or drawings for the majority of cases provide a visual guide to conditions, techniques, diagnoses, and key concepts that will further enhance your understanding and retention of all content. Content that's perfect for all levels of study or practice covers both concepts and techniques that residents and pre-doctoral students can apply in the clinical setting, and the preparation tools necessary for oral and maxillofacial surgery boards and training/certification examinations. NEW! Full-color illustrations and photos give you a better pictures of common surgical techniques and pathology. NEW! Chapter 6: Dental Implant Surgery discusses the contemporary issues related to dental implants - specifically the routine placement of maxillary and mandibular implants, sinus augmentation, zygoma implants, treatment of edentulism, guided implant surgery, extraction socket preservation, and implantology for the esthetic zone. NEW! Section on cone beam computed tomography (CBCT) highlights the role of imaging from diagnosis to image guidance for many surgical procedures. NEW! Section on the advantages of computer assisted surgery highlights virtual surgical planning for a patient who presents for combined surgical and orthodontic correction of his facial asymmetry and apertognathia. NEW! Section on trigeminal neuralgia (TN) walks you through the diagnosis and possible treatments for a patient suffering from trigeminal neuralgia, the signs and symptoms that uniquely define the disorder, and the clinician's ability to recognize the specific diagnostic pattern. NEW! Section on neck dissection, an important aspect of head and neck cancer treatment, provides a case that involves a patient in which right selective neck dissection (I-III) was conducted on the right neck and a selective left neck dissection (I-V) was completed on the left side. NEW! Section on dentoalveolar trauma presents a new case that takes you through diagnosing and treating a patient who presents with anterior maxillary alveolar segment fractures involving teeth #7-9, with lateral luxation and Ellis class III fracture tooth of #9, and an intraoral laceration of the upper lip. NEW! Section on nasal septoplasty addresses a patient with a severely deviated nasal septum to the left, involving the quadrangular cartilage and the bony septum and how septoplasty can make a dramatic change in the patient's quality of life, by facilitating nasal airflow, allowing for better spontaneous drainage of the paranasal sinuses, possibly reducing mouth breathing, and reducing or eliminating the symptoms of snoring, and perhaps lessening the severity of the obstructive sleep apnea syndrome.