Molecular Biology of the Cell
Title | Molecular Biology of the Cell PDF eBook |
Author | |
Publisher | |
Pages | 0 |
Release | 2002 |
Genre | Cells |
ISBN | 9780815332183 |
Intracellular Signals and the Regulation of Cell Division
Title | Intracellular Signals and the Regulation of Cell Division PDF eBook |
Author | Tung-Ling Li Chen |
Publisher | |
Pages | 238 |
Release | 1988 |
Genre | Cell division |
ISBN |
Regulation of Signal Transduction in Human Cell Research
Title | Regulation of Signal Transduction in Human Cell Research PDF eBook |
Author | Nariyoshi Shinomiya |
Publisher | Springer |
Pages | 220 |
Release | 2018-02-15 |
Genre | Medical |
ISBN | 9811072965 |
This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
Calcium Entry Channels in Non-Excitable Cells
Title | Calcium Entry Channels in Non-Excitable Cells PDF eBook |
Author | Juliusz Ashot Kozak |
Publisher | CRC Press |
Pages | 343 |
Release | 2017-07-14 |
Genre | Science |
ISBN | 149875273X |
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Trafficking Inside Cells
Title | Trafficking Inside Cells PDF eBook |
Author | Nava Segev |
Publisher | Springer Science & Business Media |
Pages | 459 |
Release | 2010-05-30 |
Genre | Science |
ISBN | 038793877X |
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Title | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems PDF eBook |
Author | Marc Thiriet |
Publisher | Springer Science & Business Media |
Pages | 1073 |
Release | 2012-09-26 |
Genre | Science |
ISBN | 1461443695 |
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
Biochemistry of Signal Transduction and Regulation
Title | Biochemistry of Signal Transduction and Regulation PDF eBook |
Author | Gerhard Krauss |
Publisher | John Wiley & Sons |
Pages | 558 |
Release | 2006-03-06 |
Genre | Science |
ISBN | 3527605762 |
This all-new edition of a classic text has been thoroughly revised to keep pace with the rapid progress in signal transduction research. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes. Directed to advanced students, teachers, and researchers in biochemistry and molecular biology, this book describes the molecular basis of signal transduction, regulated gene expression, the cell cycle, tumorigenesis and apoptosis. "Provides a comprehensive account of cell signaling and signal transduction and, where possible, explains these processes at the molecular level" (Angewandte Chemie) "The clear and didactic presentation makes it a textbook very useful for students and researchers not familiar with all aspects of cell regulation." (Biochemistry) "This book is actually two books: Regulation and Signal Transduction." (Drug Research)