Spinoff is NASA's annual premiere publication featuring successfully commercialized NASA technology. For more than 40 years, the NASA Commercial Technology Program has facilitated the transfer of NASA technology to the private sector, benefitting global competition and the economy. The resulting commercialization has contributed to the development of commercial products and services in the fields of health and medicine, industry, consumer goods, transportation, public health, computer technology, and environmental resources. Since 1976, Spinoff has featured between 40 and 50 of these commercial products annually.

Some vols. include supplemental journals of "such proceedings of the sessions, as, during the time they were depending, were ordered to be kept secret, and respecting which the injunction of secrecy was afterwards taken off by the order of the House".