Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. - Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field - Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources - Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics

The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis. - Explains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work on small-scale biological samples - Presents recent developments of force-based biosensing - Includes novel applications of nano-biomechanics to the medical field

By using nanotechnological methods, we can now poke around protein molecules, genes, membranes, cells and more. Observation of such entities through optical and electron microscopes tempt us to touch and manipulate them. It is now possible to do so, and scientists around the world have started pulling, pushing and cutting small structures at the base of life processes to understand the effect of our hand work.The book describes the physical properties of such life supporting structures from the molecular level with a special emphasis on their designs based on the mechanical strength and flexibility, membrane and other biological nanostructures.- Describes the basic mechanical features of proteins, DNA, cell membrane and other biological nanostructures - Explains the basic concepts and mathematics of elementary mechanics needed to understand and perform experimental work

"The World of Nano-Biomechanics, Second Edition, "focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, sub-cellular organelles, and live cells are discussed. New to this second edition are recent developments in two important applications, i.e., high-resolution mechanical biosensors and the use of cell mechanics for medical diagnosis. Fully revised and expanded new edition based on the latest research and developments in the fieldExplains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work Presents recent developments of force-based biosensorsIncludes novel applications of nano-biomechanics to the medical field

This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Because of rapid developments in computer technology and computational techniques, advances in a wide spectrum of technologies, coupled with cross-disciplinary pursuits between technology and its application to human body processes, the field of biomechanics continues to evolve. Many areas of significant progress include dynamics of musculoskeletal systems, mechanics of hard and soft tissues, mechanics of bone remodeling, mechanics of blood and air flow, flow-prosthesis interfaces, mechanics of impact, dynamics of man-machine interaction, and more. Thus, the great breadth and significance of the field in the international scene require a well integrated set of volumes to provide a complete coverage of the exciting subject of biomechanical systems technology. World-renowned contributors tackle the latest technologies in an in-depth and readable manner.

“Filled with illustrations, illuminating stories, and historical deep dives, Muscle will give you new insight into the power of our bodies.” —Milan Polk, Men’s Health An entertaining illustrated deep dive into muscle, from the discovery of human anatomy to the latest science of strength training. Muscle tissue powers every heartbeat, blink, jog, jump, and goosebump. It is the force behind the most critical bodily functions, including digestion and childbirth, as well as extreme feats of athleticism. We can mold our muscles with exercise and observe the results. In this lively, lucid book, orthopedic surgeon Roy A. Meals takes us on a wide-ranging journey through anatomy, biology, history, and health to unlock the mysteries of our muscles. He breaks down the three different types of muscle—smooth, skeletal, and cardiac—and explores major advancements in medicine and fitness, including cutting-edge gene-editing research and the science behind popular muscle conditioning strategies. Along the way, he offers insight into the changing aesthetic and cultural conception of muscle, from Michelangelo’s David to present-day bodybuilders, and shares fascinating examples of strange muscular maladies and their treatment. Brimming with fun facts and infectious enthusiasm, Muscle sheds light on the astonishing, essential tissue that moves us through life.