New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. - Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies - Highlights the potential future role of natural products in preventative medicine - Supported by real world case studies throughout

One of the hottest topics in computer forensics today, electronic discovery (e-discovery) is the process by which parties involved in litigation respond to requests to produce electronically stored information (ESI). According to the 2007 Socha-Gelbmann Electronic Discovery Survey, it is now a $2 billion industry, a 60% increase from 2004, projected to double by 2009. The core reason for the explosion of e-discovery is sheer volume; evidence is digital and 75% of modern day lawsuits entail e-discovery.A recent survey reports that U.S. companies face an average of 305 pending lawsuits internationally. For large U.S. companies ($1 billion or more in revenue)that number has soared to 556 on average, with an average of 50 new disputes emerging each year for nearly half of them. To properly manage the role of digital information in an investigative or legal setting, an enterprise--whether it is a Fortune 500 company, a small accounting firm or a vast government agency--must develop an effective electronic discovery program. Since the amendments to the Federal Rules of Civil Procedure, which took effect in December 2006, it is even more vital that the lifecycle of electronically stored information be understood and properly managed to avoid risks and costly mistakes. This books holds the keys to success for systems administrators, information security and other IT department personnel who are charged with aiding the e-discovery process. - Comprehensive resource for corporate technologists, records managers, consultants, and legal team members to the e-discovery process, with information unavailable anywhere else - Offers a detailed understanding of key industry trends, especially the Federal Rules of Civil Procedure, that are driving the adoption of e-discovery programs - Includes vital project management metrics to help monitor workflow, gauge costs and speed the process

This book shows why and how the concepts, control and happenstance, are crucial to methodology and statistics, respectively. Control, as a means to reduce ambiguity, fulfills its function because of inductive rules. Statistical null hypothesis renders it possible to use test of statistical significance to rule out happenstance as explanation of research result. This book shows why and how the concepts, control and happenstance, are crucial to methodology and statistics, respectively. Control, as a means to reduce ambiguity, fulfills its function because of inductive rules. Statistical null hypothesis renders it possible to use tests of statistical significance to rule out happenstance as an explanation for research results. Basic concepts of descriptive statistics are introduced in the context of data collection, tabulation, derivation, and standardization. Issues related to psychometric measurement, correlation and regression are thereby explained as well. Random sampling distribution renders possible inferential statistics (viz., confidence interval, parameter estimation, hypothesis testing and goodness-of-fit). The book shows how standardizing random sampling distribution gives rise to parametric tests. In short, this book shows that research impartiality is possible despite the belief in (as well as instances of) “beauty is in the eye of the beholder.”

The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Society forges ahead in the process of solving various contradictory problems and it is ceaselessly innovating. It is the desire of mankind to use computers and computing networks to help deal with contradictory problems and to conduct innovative activities. Using formal models to discuss object extension and the possibility of change, as well as the rules and methods for innovation, Extenics is applied to solving contradictory problems and has become the basic theory, method and instrument to achieve this goal. In the 30 years since the foundation of Extenics, researchers have built relatively complete theoretical systems —‘extension theory’, studied formal and modeling innovation methods —‘extension innovation methods’, and launched the applications in various fields such as information, design, automation and management etc. —‘extension engineering’. Extension theory, the extension innovation method and extension engineering jointly constitute the new discipline—Extenics. At the same time, the practical activities of engineering technology and management promote the integration of various innovation methods such as TRIZ and brainstorming etc. This book collects together, from scholars in various fields, the research achievements in Extenics and innovation methods, in order to facilitate and promote the development of Extenics and the various innovation theories and methods, as well as to improve its innovative capacity in academic and business circles.