This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Design Innovation for Health and Medicine offers an innovative approach for solving complex healthcare issues. In this book, three design experts examine a range of case studies to explain how design is used in health and medicine—exploring issues such as diverse patient needs, an ageing population and the impact of globalisation on disease. These case studies, along with high-profile industry projects conducted by the authors over the past decade, inform a novel framework for designing and implementing innovative solutions in this context. The book aims to assist designers, medical engineers, clinicians and researchers to shape the next era of healthcare.

Over half of the world’s population is afflicted with some form of chronic or degenerative illness. Heart disease, autoimmune disease, diabetes, neurological conditions, cancer, Lyme disease—the list goes on. The conventional, allopathic, treat-the-symptom-with-pharmaceutical-drugs model is rapidly falling out of favor as patients are searching for nontoxic, advanced prevention and healing modalities that actually work. Bioregulatory Medicine introduces a model that has proven effective for decades in other more forward-thinking developed countries, including Switzerland and Germany. Our bodies have many bioregulating systems, including the cardiovascular, digestive, neurological, respiratory, endocrine, and so on. Bioregulatory medicine is a comprehensive and holistic approach to health that advocates the use of natural healing methods to support and restore the body’s intrinsic self-regulating and self-healing mechanisms, as opposed to simply treating symptoms with integrative therapies. Bioregulatory medicine is about discovering the root cause of disease and takes into account the entire person from a genetic, epigenetic, metabolic, energetic, and emotional point of view. So while patients may have the same disease or prognosis, the manifestation of illness is entirely bioindividual and must be treated and prevented on an individual level. Bioregulatory Medicine addresses the four pillars of health—drainage and detox, diet, mind-body medicine, and oral health—using a sophisticated synthesis of the very best natural medicine with modern advances in technology. In addition to identifying the cause of disease, bioregulatory medicine promotes disease prevention and early intervention of illness through noninvasive diagnostics and treatments, and incorporates the use of over 100 different non-toxic diagnostics and treatments from around the world. Forward-thinking patients and integrative practitioners will find Bioregulatory Medicine invaluable as they seek to deepen their understanding of the body’s many regulating systems and innate ability to heal itself.

Healthcare systems have been in a state of flux for a number of years now due to increasing digitalization. Medicine itself is also facing new challenges, and how to maximize the possibilities of artificial intelligence, whether digitalization can help to strengthen patient orientation, and dealing with the issue of data quality and completeness are all issues which require attention, creativity and research. This book presents the proceedings of the 64th annual conference of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS 2019), held in Dortmund, Germany, from 8 - 11 September 2019. The theme of this year’s conference is Shaping Change – Creative Solutions for Innovative Medicine, and the papers presented here focus on active participation in shaping change while ensuring that good scientific practice, evidence and regulation are not lost as a result of innovation. The book is divided into 8 sections: biostatistics; healthcare IT; interoperability - standards, classification, terminology; knowledge engineering and decision support; medical bioinformatics and systems biology; patient centered care; research infrastructure; and sociotechnical systems / usability and evaluation of healthcare IT. The book will be of interest to all those facing the challenges posed by the ongoing revolution in medicine and healthcare.

From one of America's top physicians, a "riveting," "fascinating," and "timely" (Nature) history of risk in medicine Every medical decision--whether to have chemotherapy, an X-ray, or surgery--is a risk, no matter which way you choose. In You Bet Your Life, physician Paul A. Offit argues that, from the first blood transfusions four hundred years ago to the hunt for a COVID-19 vaccine, risk has been essential to the discovery of new treatments. More importantly, understanding the risks is crucial to whether, as a society or as individuals, we accept them. Told in Offit's vigorous and rigorous style, You Bet Your Life is an entertaining history of medicine. But it also lays bare the tortured relationships between intellectual breakthroughs, political realities, and human foibles. As we have learned from the COVID pandemic--the debates over lockdowns, masks, and vaccines--it's all too easy to get everything wrong. Updated with a new introduction, You Bet Your Life is an essential read for getting the future a bit more right.

Recognize market opportunities, master the design process, and develop business acumen with this 'how-to' guide to medical technology innovation. Outlining a systematic, proven approach for innovation - identify, invent, implement - and integrating medical, engineering, and business challenges with real-world case studies, this book provides a practical guide for students and professionals.

Americans praise medical technology for saving lives and improving health. Yet, new technology is often cited as a key factor in skyrocketing medical costs. This volume, second in the Medical Innovation at the Crossroads series, examines how economic incentives for innovation are changing and what that means for the future of health care. Up-to-date with a wide variety of examples and case studies, this book explores how payment, patent, and regulatory policiesâ€"as well as the involvement of numerous government agenciesâ€"affect the introduction and use of new pharmaceuticals, medical devices, and surgical procedures. The volume also includes detailed comparisons of policies and patterns of technological innovation in Western Europe and Japan. This fact-filled and practical book will be of interest to economists, policymakers, health administrators, health care practitioners, and the concerned public.