This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

This second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases. All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.

This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

Part of the Drugs in series, this book provides an easily accessible pocket-sized guide to the use of medications when treating patients with neurological ailments. Drugs in Neurology covers the breadth of medications used in modern neurology, including each drug's indications, contra-indications, side-effects and important interactions. The underlying pharmacology also feature (where known). Practical aspects related to prescribing and therapeutic drug monitoring are covered and based on the most up-to-date evidence-based guidance. Each drug monograph contains a small section drawing on the wisdom of the senior contributors of each chapter with regards to using the medication.

1 in 6 people suffer from brain diseases like MS, Parkinson’s, and Alzheimer’s. Now, a Harvard neurologist takes you inside the brain under attack—and illuminates the path to a cure. Multiple Sclerosis. Parkinson’s Disease. Alzheimer’s. ALS. Chances are, you know someone with a neurologic disease. Because the brain controls so much and is integral to our identity, the diseases that affect it are uniquely devastating both to patients and families. And because it remains the most mysterious of our vital organs, treating the brain is an ongoing puzzle. In The Brain Under Siege, Howard Weiner likens the brain to a crime scene, showing readers how “clues” point to causes and suggest paths to a cure. He takes readers on a journey through the latest technological advances, exploring which routes of investigation have gone cold and which have led to breakthroughs. Readers couldn’t ask for a better guide: A professor of neurology at Harvard Medical School and co-director of the Ann Romney Center for Neurologic diseases, Weiner is an internationally renowned expert, who pioneered immunotherapy in MS and is currently investigating an Alzheimer’s vaccine. Informative and engaging, this groundbreaking book tells the story behind the science—painting a picture of the discoveries, setbacks, false leads, and victories on the front lines of brain research. Weiner also offers unique insight by exploring the experiences of the brave patients and families who make cutting-edge clinical trials possible. Both a clear-eyed assessment of where the science stands and a gripping and poignant narrative of the dramatic pursuit for a cure, The Brain Under Siege is a must-read for patients, families, and anyone interested in unraveling the mysteries of the brain.

The leading reference on electroencephalography since 1982, Niedermeyer's Electroencephalography is now in its thoroughly updated Sixth Edition. An international group of experts provides comprehensive coverage of the neurophysiologic and technical aspects of EEG, evoked potentials, and magnetoencephalography, as well as the clinical applications of these studies in neonates, infants, children, adults, and older adults. This edition's new lead editor, Donald Schomer, MD, has updated the technical information and added a major new chapter on artifacts. Other highlights include complete coverage of EEG in the intensive care unit and new chapters on integrating other recording devices with EEG; transcranial electrical and magnetic stimulation; EEG/TMS in evaluation of cognitive and mood disorders; and sleep in premature infants, children and adolescents, and the elderly. A companion website includes fully searchable text and image bank.