Papers from a 1989 workshop, held in Maastricht, the Netherlands, under the auspices of the United Nations University and the International Federation of Institutes for Advanced Study, look at industrial development in the face of global environmental change, using the analogy that convert raw materials and energy into finished products. Examines case histories from the US, Europe, and India. No index. Annotation copyright by Book News, Inc., Portland, OR

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Discusses a different approach to addressing environmental problems, aimed at a broad interdisciplinary audience.

This book makes the case for why we should care about islands and their sustainability. Islands are hotspots of biocultural diversity and home to 600 million people that depend on one-sixth of the earth’s total area, including the surrounding oceans, for their subsistence. Today, they are at the frontlines of climate change and face an existential crisis. Islands are, however, potential “hubs of innovation” that are uniquely positioned to be leaders in sustainability and climate action. This volume argues that a full-fledged program on “island industrial ecology” is urgently needed, with the aim of offering policy-relevant insights and strategies to sustain small islands in an era of global environmental change. The nine contributions in this volume cover a wide range of applications of socio-metabolic research, from flow accounts to stock analysis and their relationship to services in space and time. They offer insights into how reconfiguring patterns of resource use will allow island governments to build resilience and adapt to the challenges of climate change.

How can we design more sustainable industrial and urban systems that reduce environmental impacts while supporting a high quality of life for everyone? What progress has been made towards reducing resource use and waste, and what are the prospects for more resilient, material-efficient economies? What are the environmental and social impacts of global supply chains and how can they be measured and improved? Such questions are at the heart of the emerging discipline of industrial ecology, covered in Taking Stock of Industrial Ecology. Leading authors, researchers and practitioners review how far industrial ecology has developed and current issues and concerns, with illustrations of what the industrial ecology paradigm has achieved in public policy, corporate strategy and industrial practice. It provides an introduction for students coming to industrial ecology and for professionals who wish to understand what industrial ecology can offer, a reference for researchers and practitioners and a source of case studies for teachers.

Over this last decade, the concept of Social Metabolism has gained prestige as a theoretical instrument for the required analysis, to such an extent that there are now dozens of researchers, hundreds of articles and several books that have adopted and use this concept. However, there is a great deal of variety in terms of definitions and interpretations, as well as different methodologies around this concept, which prevents the consolidation of a unified field of new knowledge. The fundamental aim of the book is to conduct a review of the past and present usage of the concept of social metabolism, its origins and history, as well as the main currents or schools that exist around this concept. At the same time, the reviews and discussions included are used by the authors as starting points to draw conclusions and propose a theory of socio-ecological transformations. The theoretical and methodological innovations of this book include a distinction of two types of metabolic processes: tangible and intangible; the analysis of the social metabolism at different scales (in space and time) and a theory of socio-ecological change overcoming the merely “systemic” or “cybernetic” nature of conventional approaches, giving special protagonism to collective action.