For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

As malaria and other tropical diseases continue their resurgence, questions about the potential impacts of environmental and demographic factors are becoming more critical. Recent attempts to understand the increase in malaria incidence often acknowledge the importance of social, economic and other contextual variables, but fail to explicitly incorporate them into models or consider how they evolve in relation to one another. This problem is of crucial interest to the climate policy community, which has been buffeted by claims and counter-claims concerning the impact of climate change on malaria. This important volume examines the contextual determinants of malaria and attempts to develop methods for incorporating them into projections of future incidence. Internationally renowned health specialists, economists, and other social scientists provide regional and global perspectives on risk modeling, the history of eradication efforts, current determinants (including environmental, social, and economic factors), and prospects for new vaccines and drugs. The Contextual Determinants of Malaria argues that an association of climate change with increased malaria incidence will have at least as much to do with human aging, poverty, urbanization, and population movement as with a rise in global temperatures. By placing climate in this perspective, The Contextual Determinants of Malaria focuses attention on the public health needs most critical in both the immediate and long-term future. It encourages multidisciplinary analysis of malaria control, and improves our understanding of the interactions of the diverse range of factors involved in the incidence and spread of the disease.

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

This publication describes the history of malaria in Sri Lanka, detailing the steps taken towards its elimination and the subsequent strategies and policies implemented to prevent its re-establishment. It highlights the challenges and lessons learned during the elimination process and describes the essential elements required for sustaining a malaria-free status, considering Sri Lanka's ongoing susceptibility. When Sri Lanka joined the Global Malaria Eradication Programme (GMEP) in the 1950s, malaria had been endemic for centuries. Following the reduction of malaria cases to near elimination levels by 1963, Sri Lanka experienced a resurgence that persisted for 5 decades. In the late 1990s, aligning with the WHO Roll Back Malaria initiative, Sri Lanka successful renewed its efforts to defeat the disease. The last indigenous malaria cases were reported in 2012, and Sri Lanka was certified malaria-free by WHO in 2016. A robust prevention of re-establishment programme has maintained zero indigenous malaria post-elimination. The insights derived from Sri Lanka's experience offer valuable guidance for other countries striving to eliminate malaria and prevent its re-establishment, making this publication a pertinent resource for researchers, public health officials, and policymakers in the field of global health.