This volume is an indispensable reference on the nature of immune defects in rodents and the special techniques necessary to maintain and breed them. The authors describe 64 inbred, hybrid, and mutant strains of rodents, each with some immune defect; explain mechanisms for ensuring genetic purity; and provide a standardized nomenclature for different varieties. Subsequent sections summarize and provide references on the genetics, pathophysiology, husbandry, and reproduction of each of the various strains as well as sound advice on planning for the selection, transportation, housing, and maintenance of these animals.

This informative guide provides a comprehensive overview of the biology and care of immunodeficient rodents, which are essential for the study of human diseases and the development of new treatments. It is an invaluable resource for scientists, veterinarians, and animal care professionals. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

This volume is an indispensable reference on the nature of immune defects in rodents and the special techniques necessary to maintain and breed them. The authors describe 64 inbred, hybrid, and mutant strains of rodents, each with some immune defect; explain mechanisms for ensuring genetic purity; and provide a standardized nomenclature for different varieties. Subsequent sections summarize and provide references on the genetics, pathophysiology, husbandry, and reproduction of each of the various strains as well as sound advice on planning for the selection, transportation, housing, and maintenance of these animals.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Immunodeficient Rodents: A Guide To Their Immunobiology, Husbandry, And Use illustrated Institute of Laboratory Animal Resources (U.S.). Committee on Immunologically Compromised Rodents National Academies, 1989 Science; Life Sciences; Biology; General; Electronic books; Immunological deficiency syndromes; Immunological deficiency syndromes - Animal models; Immunological deficiency syndromes/ Animal models; Medical / Immunology; Nature / Animals / Mammals; Nature / Mammals; Rodents; Rodents - Immunology; Rodents as laboratory animals; Rodents/ Immunology; Science / Life Sciences / Biology / General; Science / Life Sciences / General; Science / Life Sciences / Zoology / General; Science / Life Sciences / Zoology / Mammals

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.