Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference

Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference
Title Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference PDF eBook
Author Steven P. Templeton
Publisher Frontiers Media SA
Pages 440
Release 2019-01-24
Genre
ISBN 288945682X

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Fungi are found in virtually every environment, and comprise a significant portion of the normal microflora of healthy individuals. Some species of fungi are aeroallergen sources capable of inducing sensitization and causing exacerbation of asthma and respiratory allergy. Others are transmissible between hosts and may cause no symptoms in healthy individuals. However, immune suppressed individuals may develop invasive disease marked by tissue invasion with a potential for widespread dissemination. Existing therapies for patients consist of antifungal drugs, yet these require prolonged administration with the possibility of adverse side effects, and may be rendered ineffective by the emergence of antifungal-resistant strains. It is therefore of interest to increase our understanding of host-pathogen interactions in order to facilitate the development of new therapies for individuals suffering from fungal infection and disease. These early interactions are shaped by an array of constituent and secreted factors that stimulate or inhibit host immune responses toward protective or detrimental immunity. Likewise, an array of preformed factors and tissue-resident cells provide early protection from fungal infection and provide extracellular signals that result in localized recruitment of inflammatory cells and determine the character of subsequent adaptive antifungal immunity. This Research Topic explores the host and fungal pathways that program innate and adaptive immunity and the immune cells, molecules, and regulatory pathways that comprise protective or detrimental responses to fungal exposure or infection. Over 200 authors contributed reviews, opinions, or original research focusing on antifungal immunity in humans and in experimental models. We believe that the results of these efforts provide a benchmark for further advances and improved antifungal therapies.

Molecular Biology of the Cell

Molecular Biology of the Cell
Title Molecular Biology of the Cell PDF eBook
Author
Publisher
Pages 0
Release 2002
Genre Cells
ISBN 9780815332183

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Recent Trends in Mycological Research

Recent Trends in Mycological Research
Title Recent Trends in Mycological Research PDF eBook
Author Ajar Nath Yadav
Publisher Springer Nature
Pages 503
Release 2021-02-04
Genre Science
ISBN 3030606597

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Fungi range from being microscopic, single-celled yeasts to multicellular and heterotrophic in nature. Fungal communities have been found in vast ranges of environmental conditions. They can be associated with plants epiphytically, endophytically, or rhizospherically. Extreme environments represent unique ecosystems that harbor novel biodiversity of fungal communities. Interest in the exploration of fungal diversity has been spurred by the fact that fungi perform numerous functions integral in sustaining the biosphere, ranging from nutrient cycling to environmental detoxification, which involves processes like augmentation, supplementation, and recycling of plant nutrients - a particularly important process in sustainable agriculture. Fungal communities from natural and extreme habitats help promote plant growth, enhance crop yield, and enhance soil fertility via direct or indirect plant growth promoting (PGP) mechanisms of solubilization of phosphorus, potassium, and zinc, production of ammonia, hydrogen cyanides, phytohormones, Fe-chelating compounds, extracellular hydrolytic enzymes, and bioactive secondary metabolites. These PGP fungi could be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in eco-friendly manners for sustainable agriculture and environments. Along with agricultural applications, medically important fungi play a significant role for human health. Fungal communities are useful for sustainable environments as they are used for bioremediation which is the use of microorganisms' metabolism to degrade waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Fungi could be used as mycoremediation for the future of environmental sustainability. Fungi and fungal products have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, and noble metals either by chemical modification or by manipulating chemical bioavailability. The two volumes of Recent Trends in Mycological Research aim to provide an understanding of fungal communities from diverse environmental habitats and their potential applications in agriculture, medical, environments and industry. The books are useful to scientists, researchers, and students involved in microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.

The Fungal Kingdom

The Fungal Kingdom
Title The Fungal Kingdom PDF eBook
Author Joseph Heitman
Publisher John Wiley & Sons
Pages 1161
Release 2020-07-10
Genre Medical
ISBN 1555819583

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Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.

Infectious Diseases in the Intensive Care Unit

Infectious Diseases in the Intensive Care Unit
Title Infectious Diseases in the Intensive Care Unit PDF eBook
Author Manish Soneja
Publisher Springer Nature
Pages 404
Release 2020-07-31
Genre Medical
ISBN 981154039X

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Infections in intensive care is a very broad topic, and this book provides concise yet comprehensive coverage. It focuses on the appropriate and judicious use of microbiological, radiological and point-of-care tests in diagnostic work-ups and evidence-based management protocols. Moreover, it offers essential information on the diagnosis and management of commonly encountered infections in the intensive care unit, making it a handy ready-reference manual for intensivists.

Aspergillus Fumigatus and Aspergillosis

Aspergillus Fumigatus and Aspergillosis
Title Aspergillus Fumigatus and Aspergillosis PDF eBook
Author Jean-Paul Latgé
Publisher
Pages 612
Release 2009
Genre Science
ISBN

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Offers the latest insights into the fundamental biology and pathogenesis of A. fumigatus. Provides a combined synopsis of both A. fumigatus and its diseases and therapies. Encompasses the most up-to-date knowledge to serve as a resource guide for the next decade of study on this organism and the many diseases it causes. Covers the fundamental biology of A. fumigatus including specific features in genetics, biochemistry, and cell biology that can explain the virulence of this opportunistic pathogen. Discusses the wide range of clinical infection, plus the latest diagnostic and treatment strategies, in specific patient populations.

Fungal Immunology:

Fungal Immunology:
Title Fungal Immunology: PDF eBook
Author Paul L. Fidel
Publisher Springer Science & Business Media
Pages 506
Release 2006-04-09
Genre Medical
ISBN 0387254455

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A comprehensive review of all known immune mechanisms for medically important fungal pathogens from the organ perspectives of the human body. This authoritative guide is organized by organ system, as one particular fungus can have several different effects.