Immune Recognition and Evasion: Molecular Aspects of Host–Parasite Interaction
Title | Immune Recognition and Evasion: Molecular Aspects of Host–Parasite Interaction PDF eBook |
Author | L.H.T. Van Der Ploeg |
Publisher | Elsevier |
Pages | 332 |
Release | 2012-12-02 |
Genre | Medical |
ISBN | 0323155669 |
Immune Recognition and Evasion: Molecular Aspects of Host-Parasite Interaction reviews recent advances in understanding the genetic basis of host-parasite interactions, with emphasis on antigenic epitopes, the genetics of parasites, the molecular mechanisms of immune recognition and evasion, and the way that cytokines and hormones act on host-parasite interactions. Organized into four parts encompassing 25 chapters, this volume begins with an overview of the genomic organization of the T cell receptor genes and the contribution of non-B DNA structures to switch recombination in immunoglobulin genes. It then discusses signal transduction by class II molecules encoded by the major histocompatibility complex la and the biological consequences of this process; allelic polymorphism of HLA class II antigens and its connection to the molecular basis of autoimmunity; mimicry between HLAB27 and bacteria; and genetic control of susceptibility to helminth infection. The reader is also introduced to recognition of protein antigens by antibodies; recognition of influenza antigens by class I-restricted cytotoxic T lymphocytes; the biochemical basis of cachexia of infection; mechanisms of antigenic variation in Plasmodium; and rational design of trypanocidal drugs. Geneticists and molecular biologists will gain valuable information from this book.
Host-Parasite Interactions
Title | Host-Parasite Interactions PDF eBook |
Author | Gert Flik |
Publisher | Garland Science |
Pages | 256 |
Release | 2004-06-01 |
Genre | Science |
ISBN | 0203487702 |
This volume summarizes current research into the physiology and molecular biology of host-parasite interactions. Brought together by leading international experts in the field, the first section outlines fundamental processes, followed by specific examples in the concluding section. Covering a wide range of organisms, Host-Parasite Interactions is essential reading for researchers in the field.
Janeway's Immunobiology
Title | Janeway's Immunobiology PDF eBook |
Author | Kenneth Murphy |
Publisher | Garland Science |
Pages | |
Release | 2010-06-22 |
Genre | Medical |
ISBN | 9780815344575 |
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Molecular Recognition in Host-Parasite Interactions
Title | Molecular Recognition in Host-Parasite Interactions PDF eBook |
Author | Timo K. Korhonen |
Publisher | Springer Science & Business Media |
Pages | 230 |
Release | 2012-12-06 |
Genre | Medical |
ISBN | 1461530385 |
A very early step in microbial colonization and pathogenesis is that involving recog nition of the host by the microbe. In the final analysis such recognition is due to interaction between specific molecules on the two sides, without which host and microbe would ignore each other. It is therefore exciting to learn the rules that govern host-microbe interaction at to a large extent determines whether or not we are infected by the molecular level, which influenza virus, leishmanias, staphylococci and other pathogens. This book is a compendium of the addresses delivered at a symposium on molecular interaction at Porvoo, Finland in August 1991. Realizing that there are no a priori differ ences in receptor recognition in viruses, eukaryotic parasites and bacteria, we freely inter mingled these microbes at the symposium, and in this book. We found the interdisciplinary discussions and comparisons both educative and stimulating. Thus the book is divided into parts that focus on host cell receptors, on microbial recognition molecules and molecules that mediate microbial interaction with a host cell receptor and, briefly, on the molecular events that follow. Although many microbes and many cellular receptors are missing from the book -owing to the limited duration and size of the symposium -the articles presented here constitute an impressive body of examples of how initial host-microbe interaction can come about. We believe that as such the book is a useful and interesting overview of the mechanisms and principles involved in these interactions.
Immunity to Parasites
Title | Immunity to Parasites PDF eBook |
Author | Derek Wakelin |
Publisher | Cambridge University Press |
Pages | 226 |
Release | 1996-08-13 |
Genre | Medical |
ISBN | 9780521436359 |
Parasites cause many important diseases in humans and domestic animals, malaria being an example. Parasites have evolved to exploit hosts' bodies whereas hosts have evolved immune systems to control infections. Host-parasite interactions therefore provide fascinating examples of evolutionary 'arms-races' in which the immune system plays a key role. Modern research in immunoparasitology is directed towards understanding and exploiting the capacity to develop effective anti-parasite immunity. By concentrating on selected infections where research has made significant progress, Immunity to Parasites provides a clear account of how host immune responses operate and how parasites can evade immunity. The experimental basis of this research is emphasised throughout. This completely updated second edition includes an expanded section on anti-parasite vaccines. The text is aimed at undergraduates and postgraduates with interests in either parasitology or immunology and provides introductory sections on these topics to lead the reader into the later chapters.
Host-Parasite Cellular and Molecular Interactions in Protozoal Infections
Title | Host-Parasite Cellular and Molecular Interactions in Protozoal Infections PDF eBook |
Author | K.-P. Chang |
Publisher | Springer Science & Business Media |
Pages | 426 |
Release | 2013-06-29 |
Genre | Science |
ISBN | 3642728405 |
Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions at the cellular and molecular level. Unique molecules produced by unusual pathways of these parasites have also been discovered and found to play important roles in their survival in the host. Understanding these mechanisms and pathways is essential not only to formulate a rational strategy for chemo- and immuno-prophylaxis and -therapy but also to unravel the mystery of biological evolution in symbiosis and parasitism. In the advent of our knowledge on the molecular biology and biochemistry of parasite membrane and other molecules, it is opportune to examine and discuss their possible roles in host-parasite recognition and interaction in a comparative approach. To highlight the recent advances of this area in various host-parasite systems, a NATO advanced Research Workshop was held from September 27 to October 1, 1986 at Hotel Villa del Mare, Acquafredda di Maratea, Italy.
Cell Signaling in Host–Pathogen Interactions: The Host Point of View
Title | Cell Signaling in Host–Pathogen Interactions: The Host Point of View PDF eBook |
Author | Diana Bahia |
Publisher | Frontiers Media SA |
Pages | 414 |
Release | 2018-03-23 |
Genre | |
ISBN | 288945455X |
The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens.