Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. - Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes - Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections - Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches - Provides information on the new strategies for drug development in this field - Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader's strategy for addressing therapeutic immune modulations

For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent.

Dive into the comprehensive world of HIV/AIDS with 'Comprehensive Insights into HIV/AIDS: From Pathogenesis to Holistic Health.' This treatise delves deep into the multifaceted realm of HIV/AIDS, offering an extensive exploration from the fundamental virology and immunological responses to the intricate pathogenesis of the virus. Unravel the global epidemiology, transmission modes, and viral structure, gaining a nuanced understanding of this complex disease. Beyond the scientific intricacies, this treatise broadens the horizon, delving into HIV testing methodologies, clinical stages, and associated complications like opportunistic infections and malignancies. It elucidates the interplay between HIV and the immune system, discussing CD4 T-cell depletion and the impact on immune function, while delving into the role of antiretroviral therapy (ART) in immune restoration. But this treatise doesn't stop at the medical spectrum. It embraces a holistic approach, exploring the psychological and societal dimensions of HIV/AIDS. From stigma and discrimination to psychosocial support, prevention strategies, and ethical considerations, it emphasizes the importance of mental well-being, education, and ethical frameworks in combating this global challenge. Experience a comprehensive journey, navigating through the landscape of HIV/AIDS research, treatment, ethical considerations, and societal implications. This treatise is a definitive guide, merging scientific depth with a holistic perspective, catering to healthcare professionals, researchers, students, and anyone passionate about understanding and addressing the multifaceted aspects of HIV/AIDS.

The long-awaited third edition of Pediatric Chiropractic takes the valuable second edition to a whole new level, offering new chapters, full-color photos, illustrations, and tables to provide the family wellness chiropractor and the student of chiropractic a valuable reference manual covering all aspects of care for the pediatric and prenatal populations. Internationally recognized authorities Claudia Anrig, DC and Gregory Plaugher, DC have invited the leaders in their fields to contribute to this precedent-setting textbook and now offer even more valuable information for the practitioner.

Mainstream medicine in America focuses on symptoms rather than causes of chronic illness and poor health. Medical education is influenced to a great extent by pharmaceutical companies and focuses our attention dangerously onto drug therapies. Conventional medicine practice has been failing miserably to control or treat the chronic disease entities afflicting our population in the modern era. Integrative medicine concepts and practice offer people much safer and often more effective options for achieving and maintaining health, as well as combating most forms of chronic disease. The keys include understanding what it really takes to promote human health in a broad sense and what the underlying causes of chronic disease truly are. Thinking Outside the Pill Box contains an explanation of how our medical system came to be so defective and ineffectual, a thorough look at the important factors influencing human health, and an in-depth discussion of many common underlying causes of chronic illness in the modern world. It is designed as a self-help book for both the reader and their future generations.

In this comprehensive guide, Dr. Bock shares his cutting-edge approach that tells readers exactly how to boost their immune systems to their maximum effectiveness. Grounded in solid medicine, but including unconventional therapies, his book shows readers how to evaluate their individual needs, then address them with tailor-made diet, exercise, supplement, and relaxation therapies.