Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applications This book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational challenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on computing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols. Part II concentrates on analysis of DNA sequencing data, covering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along with methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for viral quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis. Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance computing, machine learning, and inference algorithms Discusses the mathematical and computational challenges in NGS technologies Covers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and more This text is a reference for biomedical professionals interested in expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics.

This is the proceedings of the Fourth Workshop on Computing: Theory and Practice, WCTP 2015 devoted to theoretical and practical approaches to computation. This workshop was organized by four top universities in Japan and the Philippines: Tokyo Institute of Technology, Osaka University, University of the Philippines - Diliman, and De La Salle University. The proceedings provides a view of the current movement in research in these two countries. The papers included in the proceedings focus on the two research areas: theoretical and practical aspects of computation.

This volume contains 68 papers presented at SCI 2016: First International Conference on Smart Computing and Informatics. The conference was held during 3-4 March 2017, Visakhapatnam, India and organized communally by ANITS, Visakhapatnam and supported technically by CSI Division V – Education and Research and PRF, Vizag. This volume contains papers mainly focused on smart computing for cloud storage, data mining and software analysis, and image processing.