This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: · Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages · The genetics of Huntington's disease, including new information on its epidemiology discussions of new testing guidelines · Neurobiology, including recent insights into correlations between pathology and symptoms and a new chapter on neuronal circuitry · The molecular biology of Huntington's disease, including new chapters on the normal function of huntingtin, the molecular pathogenesis of Huntington's disease and the peripheral pathology of the disorder, and an extensively updated chapter on its structural biology · An updated description of the comprehensive care for Huntington's disease, featureing a new chapter on preclinical therapeutics and a completely rewritten chapter on the state of the art of experimental therapeutics and clinical trials.

Henry E. Huntington, nephew and protégé of Southern Pacific Railroad magnate Collis Huntington, decided to invest his fortune in developing interurban railroads serving the Los Angeles Basin, beginning in 1898 and working through 1920. With enough capital to put railroads where he felt they would work best, he exerted considerable influence on the early growth of Southern California. He also invested in a number of other regional industries, and as an avid collector of rare books and art, he and his second wife Arabella created a notable cultural legacy as well.

A legendary book collector, a connoisseur of fine art, a horticulturist, and a philanthropist, Henry Edwards Huntington is perhaps best known as the founder of the world-renowned Huntington Library, Art Gallery, and Botanical Gardens in San Marino, California. James Thorpe's comprehensive biography of Huntington tells the richly human story of the man who became America's greatest book collector and was a leading figure in the development of southern California. Henry Edwards Huntington was born in New York State in 1850. He began working at the age of 17, eventually moved to California, and in later years was hailed for his vision in developing the street railway system that created the structure of the Los Angeles area. Always a lover of books, Huntington acquired many spectacular volumes—among them the complete Gutenberg Bible on vellum and the library of the Earl of Bridgewater. He also built a splendid art collection and established a grand botanical garden on the grounds of the buildings that would house his art and books. Then, in an act of philanthropy seldom equaled, he gave these great treasures to the public. The intimate side of Huntington's life appears in these pages, too. Thorpe has culled a vast trove of private letters, diaries, and other documents that reveal Huntington's exceptional personal qualities. The author's well-rounded biography of this unassuming yet gifted American is also richly evocative of the times in which Henry Edwards Huntington lived.