Covering all of the main aspects of pharmacology. This book includes line drawings and figures to illustrate concepts and mechanisms of action. It ends with a selection of recommended reading and multiple choice revision questions. It allows readers to appreciate why and how certain drugs alleviate the symptoms of disease.

Focusing on the essential aspects of pharmacology you need to know, Brody's Human Pharmacology, 6th Edition, keeps you fully up to date with all that's new in the field. Streamlined content, a new organizational approach, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information. The 6th Edition of this easy-to-use text is now fully up to date with: - NEW chapter devoted entirely to pharmacogenomics and personalized medicine. - NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states. - NEW chapters on recent developments in the treatment of Alzheimer's disease, ADHD and the latest treatments for HIV. - NEW section on pain management. - NEW section in each chapter covering "Clinical Relevance for Healthcare Professionals" that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals. Plus these student-friendly features: - A new organizational approach, focusing on integration and systems-based learning. - Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects. - USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix. Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com

Unique among pharmacology textbooks, HUMAN PHARMACOLOGY: MOLECULAR TO CLINICAL organizes drugs of a class according to the characteristics of the class, with individual drugs discussed in relation to other drugs of the class. This approach helps students understand strengths and weaknesses of drugs, both in comparison with each other and in certain clinical conditions. The standard format allows for quick reference, and the more than 400 full-color illustrations focus on processes and mechanisms. Material is current, with changes reflecting today's pharmacotherapy. Unique New Horizons section discusses drugs being evaluated by the FDA for use in the next two to three years. Hundreds of color-coded boxes and tables allow for rapid access, and summary tables are now more "crammable." Superb index gives user quick access to specific information. Hundreds of excellent color illustrations describe important processes, structures, and interactions. USMLE-type questions at the ends of chapters allow for on-going self-assessment.

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Thoroughly updated from the previous edition, this book provides an overview of the most important aspects of pharmacology--focusing on the concepts, clinical applications, and side effects that are considered essential knowledge in the field. Covers gene therapy, eating disorders and obesity, herbal and natural products, the treatment of neurological disorders, including Alzheimer's disease, and other rapid expanding areas.

Experts estimate that as many as 98,000 people die in any given year from medical errors that occur in hospitals. That's more than die from motor vehicle accidents, breast cancer, or AIDSâ€"three causes that receive far more public attention. Indeed, more people die annually from medication errors than from workplace injuries. Add the financial cost to the human tragedy, and medical error easily rises to the top ranks of urgent, widespread public problems. To Err Is Human breaks the silence that has surrounded medical errors and their consequenceâ€"but not by pointing fingers at caring health care professionals who make honest mistakes. After all, to err is human. Instead, this book sets forth a national agendaâ€"with state and local implicationsâ€"for reducing medical errors and improving patient safety through the design of a safer health system. This volume reveals the often startling statistics of medical error and the disparity between the incidence of error and public perception of it, given many patients' expectations that the medical profession always performs perfectly. A careful examination is made of how the surrounding forces of legislation, regulation, and market activity influence the quality of care provided by health care organizations and then looks at their handling of medical mistakes. Using a detailed case study, the book reviews the current understanding of why these mistakes happen. A key theme is that legitimate liability concerns discourage reporting of errorsâ€"which begs the question, "How can we learn from our mistakes?" Balancing regulatory versus market-based initiatives and public versus private efforts, the Institute of Medicine presents wide-ranging recommendations for improving patient safety, in the areas of leadership, improved data collection and analysis, and development of effective systems at the level of direct patient care. To Err Is Human asserts that the problem is not bad people in health careâ€"it is that good people are working in bad systems that need to be made safer. Comprehensive and straightforward, this book offers a clear prescription for raising the level of patient safety in American health care. It also explains how patients themselves can influence the quality of care that they receive once they check into the hospital. This book will be vitally important to federal, state, and local health policy makers and regulators, health professional licensing officials, hospital administrators, medical educators and students, health caregivers, health journalists, patient advocatesâ€"as well as patients themselves. First in a series of publications from the Quality of Health Care in America, a project initiated by the Institute of Medicine