Nineteen cutting-edge articles by leading practitioners review critical issues concerning biocompatible materials-polymers, metals, and other materials-used in or on the human body. Topics range from biopolymers used in controlled release drug delivery systems and synthetic burn-wound dressings to specific orthopedic devices. Each application-oriented article integrates basic science, engineering and medical experience with discussions of quality control. The contributors offer a wealth of valuable data and experience to materials scientists, research engineers, and academic physicians and surgeons. Their many examples provide rich insights into our experience today with a broad spectrum of modern biomaterials applications.

The medical device and drug industries standards in analytical methodology and are consistently among the strongest techno- quality control. logical performers. Materials are a key The users of Biomaterials Engineering ingredient in their dynamic growth. Devel- and Devices: Human Applications will r- opment of these materials is in a constant resent a broad base of backgrounds ranging state of activity, with the challenge of re- from the basic sciences (e. g. , polymer placing old materials that cannot withstand chemistry and biochemistry) to more the tests of time, and the new materials’ applied disciplines (e. g. , mechanical/ needs coming to the forefront in modern chemical engineering, orthopedics, and applications. This new reference text, pharmaceutics). To meet varied needs, each Biomaterials Engineering and Devices: chapter provides clear ancd fully detailed Human Applications, focuses on materials discussions. This in-depth, but practical, used in or on the human body—materials coverage should also assist recent indu- that define the world of “biomaterials. ” ees to the biomaterials circle. The editors Biomaterials Engineering and Devices: trust that this reference textbook conveys Human Applications focuses on mate- the intensity of this fast moving field in an rials development and characterization. enthusastic presentation. Chapters deal with issues in the selection of Donald L. Wise, PHD proper biomaterials from biocompatibility Debra J. Trantolo, PHD to biostability to structure/function relation- Kai-Uwe Lewandrowski, MD ships. Chapters also focus on the use of Joseph D. Gresser, PHD specific biomaterials based on their physio- Mario V.

Authoritative international experts comprehensively review many current state-of-the-art uses of polymers, metals, and ceramics in the human body. A veritable encyclopedia of valuable data and experience, this volume not only fully addresses the major issues of compatibility and functionality, but also provides a technical treatise on the design and evaluation of biomaterials for vascular application and on biomaterials as carriers for bioactive agents. A second volume, Biomaterials Engineering and Devices: Human Applications, Volume 2 is devoted to biomaterials for dental applications, bony biomaterials for grafting applications, and orthopedic fixtures and cements. Extensively illustrated and referenced, Biomaterials Engineering and Devices: Human Applications, Volume 1: Fundamentals and Vascular and Carrier Applications integrates for today's bioengineering professionals the basic science, engineering, and practical medical experience needed to meet the ever-growing demand for new and better biomaterials.

This book highlights recent advances in the field of biomaterials design and the state of the art in biomaterials applications for biomedicine. Addressing key aspects of biomaterials, the book explores technological advances at multi-scale levels (macro, micro, and nano), which are used in applications related to cell and tissue regeneration. The book also discusses the future scope of bio-integrated systems. The contents are supplemented by illustrated examples, and schematics of molecular and cellular interactions with biomaterials/scaffolds are included to promote a better understanding of the complex biological mechanisms involved in material-to-biomolecule interactions. The book also covers factors that govern cell growth, differentiation, and regeneration in connection with the treatment and recovery of native biological systems. Tissue engineering, drug screening and delivery, and electrolyte complexes for biomedical applications are also covered in detail. This book offers a comprehensive reference guide for multi-disciplinary communities working in the area of biomaterials, and will benefit researchers and graduate students alike.

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

A concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue engineering is examined in detail. This is the first work to specifically covers topics of interest with regards to the biomaterial component. The book is divided into 2 sections: (i) general materials technology (e.g., fibrous tissue scaffolds) and (ii) applications in the engineering of specific tissues (e.g., materials for cartilage tissue engineering). Each chapter covers the fundamentals and reflects not only a review of the literature, but also addresses the future of the topic. The book is intended for an audience of researchers in both industry and academia that are interested in a concise overview regarding the biomaterials component of tissue engineering, a topic that is timely and only growing as a field.

With sixty years of combined experience, the authors of this extensively revised book have learned to emphasize the fundamental materials science, structure-property relationships, and biological responses as a foundation for a wide array of biomaterials applications. This edition includes a new chapter on tissue engineering and regenerative medicine, approximately 1900 references to additional reading, extensive tutorial materials on new developments in spinal implants and fixation techniques and theory. It also offers systematic coverage of orthopedic implants, and expanded treatment of ceramic materials and implants.