WHO has progressively strengthened its work for adolescent health, growing its portfolio of research, norms and standards, country support and advocacy, and expanding the scope of work across over 17 departments, regional and country offices to address the multifaceted needs of the global adolescent population. Central to a coordinated approach to adolescent health across the organization is the HQ Interdepartmental Technical Working Group on Adolescent Health and Well-being. In 2021, the group produced the first report on its work on adolescent health and well-being, celebrating efforts across many areas of work and all levels of the organization. This is the second in the series of biennial reports that comes on the wake of the Global Forum for Adolescents 2023 and is powered by its 1.8 Billion Young People for Change campaign. The report describes WHO’s efforts to elevate adolescent health and well-being through collaboration and by coordinating new initiatives, addressing emerging needs and establishing ambitious objectives with its development partners and adolescents. Target audience: this WHO serial publication is designed to be used by policy-makers, media and donors.