Dieser Werk behandelt umfassend und aktuell Stoffwechselveränderungen beim Menschen, die mit Wirt-Erreger-Beziehungen in Zusammenhang stehen. Teil 1 beschreibt die Anpassung pathogener Mikroben an Stoffwechselvorgänge. Teil 2 zeigt Wege für die Entwicklung neuartiger Antibiotika.

This book describes the genetics, biochemistry, and epidemiology of host-pathogen interactions in plant disease, especially as they concern the breeding of crops for disease resistance. It analyzes a wealth of information that has not previously been recorded in other books or reviews. Some of it stems from basic surveys of disease in the field. The analysis of these surveys not only explains a great deal about host-pathogen interactions that was heretofore obscure, but also indicates directions for future research. Other data, from original papers, have now been coordinated for the first time and organized in a way that suggests new areas of research. The book contains more than fifty new tables that integrate data and relate them to general principles of host-pathogen interactions.For plant pathologists and plant breeders concerned with the control of plant disease, the book shows how to manipulate the host and, indirectly, the pathogen in order to control disease. It analyzes records of resistance against disease that time has shown to be stable in an effort to determine what has kept this resistance stable. It also analyzes the structure of virulence in populations of a pathogen, and demonstrates how virulence can be deliberately restricted. The author updates information on the gene-for-gene hypothesis and discusses the numerical and biological implications of the hypothesis. He analyzes the structure of epidemics based on three fundamental variables: the initial inoculum, the progeny/parent ratio of the pathogen, and the latent period. The author concentrates on the progeny/parent ratio - a subject not hitherto probed in detail in the literature - and shows how to determine the type of epidemic that can occur.

This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide.

Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases. - Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology - Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more - Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections - Supports combinatory networking in order to find new solutions in clinical therapies - Reflects the most topical pneumococcal research trends

The book offers an integrated overview of plant–pathogen interactions. It discusses all the steps in the pathway, from the microbe–host-cell interface and the plant’s recognition of the microbe to the plant’s defense response and biochemical alterations to achieve tolerance / resistance. It also sheds light on the classes of pathogens (bacteria, fungus and viruses); effector molecules, such as PAMPs; receptor molecules like PRRs and NBS-LRR proteins; signaling components like MAPKs; regulatory molecules, such as phytohormones and miRNA; transcription factors, such as WRKY; defense-related proteins such as PR-proteins; and defensive metabolites like secondary metabolites. In addition, it examines the role of post-genomics, high-throughput technology (transcriptomics and proteomics) in studying pathogen outbreaks causing crop losses in a number of plants. Providing a comprehensive picture of plant-pathogen interaction, the updated information included in this book is valuable for all those involved in crop improvement.

In recent decades, infectious diseases, once believed to be fairly contained, have become a vital, resurgent field of research. In Host-Pathogen Interactions: Methods and Protocols, top experts examine the relationship between the host and the pathogen, crucial in the outcome of an infection and the establishment of disease or asymptomatic, commensal colonization by organisms. The step-by-step laboratory methods and protocols of this volume study host-pathogen interaction, with a focus on fungal, bacterial and parasitic pathogens, at a molecular level in order to reveal the mechanisms of infection and to identify the vulnerabilities of the pathogen of interest. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters feature brief subject introductions, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Host-Pathogen Interactions: Methods and Protocols serves as an easy entry point for all those investigating the factors responsible for the pathogenicity of microorganisms.

Besides causing direct damage associated with blood feeding and in some cases through the excretion of toxins with their saliva, the main relevance of ticks lies in the wide variety of pathogens that they can transmit, including viruses, bacteria, protozoa and helminths. Owing to socioeconomic and environmental changes, tick distribution is changing with incursions of ticks and tick-borne diseases occurring in different regions of the world when the widespread deployment of chemical acaricides and repellents has led to the selection of resistance in multiple populations of ticks. New approaches that are environmentally sustainable and that provide broad protection against current and future tick-borne pathogen (TBP) are thus urgently needed. Such development, however, requires improved understanding of factors resulting in vector competence and tick-host-pathogen interactions. This Research Topic provides an overview of known molecular tick-host-pathogen interactions for a number of TBPs and highlights how this knowledge can contribute to novel control and prevention strategies for tick-borne diseases.