This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.

Nowadays, raw biological data can be easily stored as databases in computers but extracting the required information is the real challenge for researchers. For this reason, bioinformatics tools perform a vital role in extracting and analyzing information from databases. Bioinformatics Tools and Big Data Analytics for Patient describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery for patient care. The book gives details about the recent developments in the fields of artificial intelligence, cloud computing, and data analytics. It highlights the advances in computational techniques used to perform intelligent medical tasks. Features: Presents recent developments in the fields of artificial intelligence, cloud computing, and data analytics for improved patient care. Describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery. Summarizes several strategies, analyses, and optimization methods for patient healthcare. Focuses on drug discovery and development by cloud computing and data-driven research The targeted audience comprises academics, research scholars, healthcare professionals, hospital managers, pharmaceutical chemists, the biomedical industry, software engineers, and IT professionals.

Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. - Provides in-depth knowledge of vaccine history - Covers the development of system vaccinology and their applications revolutionize the vaccine discovery - Gives insights to the development of new strategies to design efficacious and safe vaccine molecule - Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials - Highlights the importance of differential miRNA expression, microbiome after vaccination for human health - Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial - Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity - Aims to understand disease pathogenesis and host responses to infection and vaccination - Offers a seamless continuum of scientific discovery and vaccine invention

This book covers liquid chromatography, gas chromatography and capillary electrophoresis, the three main separation techniques lately available, applied to key omic sciences, such as genomics, proteomics, metabolomics and foodomics. The fundamentals of each technique are not covered herein. Instead, the recent advances in such techniques are presented focusing on the application to omics analyses and unique aspects in each case. This volume intends to offer wide ranging options available to researchers on omics sciences, and how to integrate them in order to achieve the comprehension of a biological system as a whole. Omic sciences have been of ultimate importance to comprehend the complex biochemical reactions and related events that occurs upon a biological system. The classical central dogma of molecular biology, which states that genetic information flows unidirectionally from DNA to RNA and then to proteins, has been gradually replaced by the systems biology approach. This book presents a multidisciplinary approach that explains the biological system as a whole, where the entire organism is influenced by a variety of internal events as well as by the environment, showing that each level of the biological information flux may influence the previous or the subsequent one.

This book constitutes the refereed proceedings of the 19th International Symposium on Bioinformatics Research and Applications, ISBRA 2023, held in Wrocław, Poland, during October 9–12, 2023. The 28 full papers and 16 short papers included in this book were carefully reviewed and selected from 89 submissions. They were organized in topical sections as follows: reconciling inconsistent molecular structures from biochemical databases; radiology report generation via visual recalibration and context gating-aware; sequence-based nanobody-antigen binding prediction; and hist2Vec: kernel-based embeddings for biological sequence classification.

In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.