The South Carolina 2nd Regiment Rifles was organized during the spring of 1862 using the 5th South Carolina Battalion Rifles as its nucleus. It was organized from extra companies initially intended for Orr's Rifles. These companies were organized into a battalion that was officially designated the Fifth South Carolina Infantry Battalion. The unit served in South Carolina, then was ordered to Virginia and assigned to General Jenkins' and Bratton's Brigade. It participated in the Seven Days' Battles and the conflicts at Second Manassas, Sharpsburg, and Fredericksburg. Later the regiment was with Longstreet at Suffolk and D.H. Hill in North Carolina. It moved again with Longstreet but did not take part in the Battle of Chickamauga. The unit was involved in the Knoxville operations, returned to Virginia, and saw action at The Wilderness, Spotsylvania, and Cold Harbor. After enduring the hardships of the Petersburg siege south and north of the James River, it ended the war at Appomattox.

The South Carolina 2nd Infantry Regiment Rifles was organized during the spring of 1862 using the 5th South Carolina Battalion Rifles as its nucleus. The Second South Carolina Rifles was organized from extra companies initially intended for Orr's Rifles. These companies were organized into a battalion that was officially designated the Fifth South Carolina Infantry Battalion. The unit was known more popularly as the First South Carolina Rifle Battalion. The regiment fought for most of the war in Virginia. They went with Longstreet to Georgia, but did not participate in the Battle of Chickamauga. They were engaged at Knoxville however, before returning to Virginia. The remnants of the regiment surrendered at Appomattox. Company A - Abbeville District (County), a few from Laurens District (County) and Newberry District (County) Company B - Pickens District (County) now Oconee County Company C - Pickens District (County), now inOconee County Company D - Anderson District (County) and Pickens District (County) Company E - Pickens District (County), Anderson District District (County), and Greenville District (County) Company F - Pickens District (County), Anderson District (County), Abbeville District (County) Company G - Anderson District (County), Greenville District (County), and a few from Georgia Company H - Pickens District (County) Company I - Pickens District (Seigler says there was no Company I) Company K - Abbeville District (County), Anderson District (County) and Pickens District (County) Company L (possibly also known as the Butler Guards) - Anderson District (County), a few from Greenville District (County) and Spartanburg District (County)

The South Carolina 21st Infantry Regiment was organized in November, 1861, with men from the Pee Dee region of the state. It served for some time in the Charleston area attached to General Hagood's Brigade in the Department of South Carolina, Georgia, and Florida. During the spring of 1864 it moved to Virginia and was active at Drewry's Bluff and Cold Harbor. The unit continued the fight in the Petersburg trenches, then took part in the North Carolina operations. CompaniesCompany A - Georgetown CountyCompany B - Darlington County "Wild Rifles"Company C - Chesterfield CountyCompany D - Chesterfield CountyCompany E - Chesterfield CountyCompany F - Marlboro CountyCompany G - Darlington County "William's Guards"Company H - Georgetown CountyCompany I - Marion CountyCompany K - Darlington County

The South Carolina 19th Infantry Regiment was organized during the winter of 1861-1862. It, along with the 18th was created as the last of the units formed in 1861 and did not participate in the early deployment. The 19th was involved the reorganization of the troops in the spring of 1862. They then moved to Mississippi, then to Kentucky where it saw action at Munfordsville. The 19th served with the Army of Tennessee from Murfreesboro to Atlanta, fought with Hood in Tennessee, and was active in the South Carolina Campaign and the North Carolina operations. The regiment lost 8 killed and 72 wounded at Murfreesboro, and the 10th/19th sustained 236 casualties at Chickamauga and totaled 436 men and 293 arms in December, 1863. During the Atlanta Campaign, July 22-28, the 19th reported 12 killed, 60 wounded, and 25 missing, and there were 9 killed, 34 wounded, and 8 missing at Ezra Church. It surrendered on April 26, 1865, with 76 men.

In January 1862, the Confederate Congress called upon the state of South Carolina to provide 12000 additional troops for the war effort. This led South Carolina to form the 17th through the 27th Regiments. The companies which became the SC 20th Infantry Regiment were already formed and had entered their respective camps of instruction. Many of the men were recruited in Sumter, Orangeburg, and Calhoun counties. What would become Company H, 20th SCVI were drilling at Hampton's Plantation in Diamond Hill, SC. As in every unit in the south, communities and families joined up together, and the 20th was no exception. Company I had 28 members by the name of Gunter. The Captain, all three Lieutenants and seven NCOs all held the name, thus they were called the Gunter Company. The 20th spent the early part of the war in the Charleston area, then fought in the Carolina's Campaign and surrendered at Bentonville. Companies Of The SC 20th Infantry Regiment A-Co. Anderson & Pickens Captain Partlow B-Co. Orangeburg Captain McMicheal C-Co. Lexington Captain Leaphart D-Co. Orangeburg Captain Danley E-Co. Laurens Captain Cowen F-Co. Newberry Captain Kinard G-Co. Sumter Captain Moseley H-Co. Lexington / Orangeburg Captain Ruff I-Co. Lexington / Orangeburg Captain Gunter K-Co. Lexington Captain Harmon Co M. was formed as "Keitt's Mounted Rifles"

The South Carolina 2nd Heavy Artillery Regiment also known as the 1st Artillery Regiment, was organized at Charleston, South Carolina, during the spring of 1862 using the 2nd South Carolina Artillery Battalion as its nucleus. This unit had enlisted in August, 1861, and went into service at Camp Butler, near Aiken. The 2nd Artillery spent the entire war in and around Charleston and completed their service fighting against Sherman in the Carolinas Campaign. Companies of the SC 2nd Artillery Regiment Company A - Barnwell District Company B - Barnwell and surrounding Districts Company C - Orangeburg District Company D - Darlington District and surrounding counties. Company E - Barnwell District, Aiken area. A few men from Lexington District and Edgefield District Company F - Orangeburg District (Branchville area) Company G - Barnwell District Company H - Barnwell District Company I - - Orangeburg District Company K - Edgefield District