From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.

The field of Nuclear Magnetic Resonance (NMR) has developed at a fascinating pace during the last decade. It always has been an extremely valuable tool to the organic chemist by supplying molecular "finger print" spectra at the atomic level. Unfortunately the high resolution achievable in liquid solutions could not be obtained in solids and physicists and physical chemists had to live with unresolved lines open to a wealth of curve fitting procedures and a vast amount of speculations. High resolution NMR in solids seemed to be a paradoxon. Broad structure less lines are usually encountered when dealing with NMR in solids. Only with the recent advent of mUltiple pulse, magic angle, cross-polarization, two-dimen sional and multiple-quantum spectroscopy and other techniques during the last decade it became possible to resolve finer details of nuclear spin interactions in solids. I have felt that graduate students, researchers and others beginning to get involved with these techniques needed a book which treats the principles, theo retical foundations and applications of these rather sophisticated experimental techniques. Therefore I wrote a monograph on the subject in 1976. Very soon new ideas led to the developement of "two-dimensional spectroscopy" and "multiple-quantum spectroscopy", topics which were not covered in the first edition of my book. Moreover an exponential growth of literature appeared in this area of research leaving the beginner in an awkward situation of tracing back from a current article to the roots of the experiment.

Manipulation and Dilution Tools for Ruling Abundant Species "NMR is dead" was the slogan heard in the late 1960s at least among physicists, until John S. Waugh and his co-workers initiated a series of new NMR experiments, which employed the coherent modulation of interactions by strong radiofrequency fields. A wealth of new phenomena was observed, which are summarized in the introduction for the convenience of the unbiased reader, whereas Section 2 collects the basic spin interactions observed in solids. Line-narrowing effects in dipolar coupled solids by the application of multiple pulse experiments are extensively discussed in Section 3. Numerous extensions of the basic Waugh, Huber, and Haeberlen experiment have been developed by different groups and have been applied to the nuclei IH, 9Be, 19F, 27Al, 31p, 63CU in solids. Application of this technique to a variety of systems is still in progress and should reveal interesting insights into weak spin interactions in solids. It was soon realized that rare spins could be used as monitors for molecular fields in the solid state; however, rare spin observation is difficult because of the small signal-to-noise ratio. Pines, Gibby, and Waugh introduced a new concept of cross-polarization, based on ideas of Hahn and co-workers, which allows the detection ofrare spins with increased sensitivity. The dynamics involved are treated in detail. Other sections merely list results obtained by the techniques described and demonstrate their usefulness in the investigation of dynamical problems in molec ular and solid state physics.

The magnetism of nuclear spin systems has proved an amazingly fertile ground for the creativity of researchers. This happy circumstance results from the triple benediction that nature appears to have bestowed on nuclear spins: they are sporting spies-being infinitely manipulable (one is even tempted to say malleable), not unduly coy in revealing their secrets, and having a whole treasure house of secrets to reveal in the first place. researcher with Since spin dynamics are now orchestrated by the NMR ever more subtle scores, it is important to be able to tune into the pro ceedings with precision, if one is to make sense of it at all. Fortunately, it is not terribly difficult to do so, since in many ways spin dynamics are the theoretician's dream come true: they are often finite dimensional and quite tractable with basic quantum mechanics, frequently allowing near exact treatments and readily testable predictions. This book was conceived two years ago, with the objective of providing a simple, consistent introduction to the description of the spin dynamics that one encounters in modern NMR experiments. We believed it was a good time to attempt this, since it was possible by then to give sufficiently general descriptions of powelful classes of new NMR experiments. The choice of experiments we discuss in detail is necessarily subjective, al though we hope to have given a flavor of most of the important classes of pulse sequences, including some surface coil imaging applications.

High-Resolution NMR Techniques in Organic Chemistry, Third Edition describes the most important NMR spectroscopy techniques for the structure elucidation of organic molecules and the investigation of their behaviour in solution. Appropriate for advanced undergraduate and graduate students, research chemists and NMR facility managers, this thorough revision covers practical aspects of NMR techniques and instrumentation, data collection, and spectrum interpretation. It describes all major classes of one- and two-dimensional NMR experiments including homonuclear and heteronuclear correlations, the nuclear Overhauser effect, diffusion measurements, and techniques for studying protein–ligand interactions. A trusted authority on this critical expertise, High-Resolution NMR Techniques in Organic Chemistry, Third Edition is an essential resource for every chemist and NMR spectroscopist.

Covers the dramatic developments in the past decade in the applications of high-resolution NMR to the study of solid materials such as inorganic silicates, aluminosilicates, and in particular, zeolites. Also covers a variety of NMR methods, including conventional FT NMR techniques, used to investigate sorbate-sorbent interactions and the structure of adsorbed molecules. Gives an historical background to the subject and a concise survey of basic principles and methods of high-resolution solid-state NMR. Then covers 29Si NMR of silicate solutions; general aspects of 29Si and 27Al NMR of the silicate and aluminosilicate framework; application of 29Si and 27Al NMR to silicates, aluminosilicates, and zeolites; NMR studies of nuclei other than 29Si and 27Al in zeolites and non-zeolitic silicates; high-resolution studies of adsorbed molecules, and much more.