In the mid-seventies, a new area of research has emerged in subsurface hydrology, namely sto chastic modeling of flow and transport. This development has been motivated by the recognition of the ubiquitous presence of heterogeneities in natural formations and of their effect upon transport and flow, on the one hand, and by the vast expansion of computational capability provided by elec tronic machines, on the other. Apart from this, one of the areas in which spatial variability of for mation properties plays a cardinal role is of contaminant transport, a subject of growing interest and concern. I have been quite fortunate to be engaged in research in this area from its inception and to wit ness the rapid growth of the community and of the literature on spatial variability and its impact upon subsurface hydrology. In view of this increasing interest, I decided a few years ago that it would be useful to present the subject in a systematic and comprehensive manner in order to help those who wish to engage themselves in research or application of this new field. I viewed as my primary task to analyze the large scale heterogeneity of aquifers and its effect, presuming that the reader already possesses a background in traditional hydrology. This is achieved in Parts 3, 4 and 5 of the text which incorporate the pertinent material.

This groundbreaking work connects the knowledge of system function developed in ecosystem ecology with landscape ecology's knowledge of spatial structure. The book elucidates the challenges faced by ecosystem scientists working in spatially heterogeneous systems, relevant conceptual approaches used in other disciplines and in different ecosystem types, and the importance of spatial heterogeneity in conservation resource management.

This groundbreaking work connects the knowledge of system function developed in ecosystem ecology with landscape ecology's knowledge of spatial structure. The book elucidates the challenges faced by ecosystem scientists working in spatially heterogeneous systems, relevant conceptual approaches used in other disciplines and in different ecosystem types, and the importance of spatial heterogeneity in conservation resource management.

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

International experts have contributed key chapters to this major work on groundwater contamination. Section 1: Methodology and Modeling deals with both organic and inorganic contaminants, including those from agricultural operations. Section 2: Case Studies presents contamination scenarios with both inorganic and organic chemicals including agriculturally-related constituents, such as the nitrates. This important new publication is a welcome addition to the literature and will enhance recent information on methodology, modeling and real-world situations. It is of interest to scientists and planners in local and national government; environmental chemists, geochemists, geologists, and health and safety officers; river authorities; hydrologists; and the mining and land reclamation industries.

Volume 34 of Reviews in Mineralogy focuses on methods to describe the extent and consequences of reactive flow and transport in natural subsurface systems. Since the field of reactive transport within the Earth Sciences is a highly multidisciplinary area of research, including geochemistry, geology, physics, chemistry, hydrology, and engineering, this book is an attempt to some extent bridge the gap between these different disciplines. This volume contains the contributions presented at a short course held in Golden, Colorado, October 25-27, 1996 in conjunction with the Mineralogical Society of America's (MSA) Annual Meeting with the Geological Society of America in Denver, Colorado.