In this issue of Clinics in Liver Disease, guest editor Mitchell L Shiffman brings considerable expertise to the topic of Challenging Issues in the Management of Chronic Hepatitis B Virus. Provides in-depth, clinical reviews on the latest updates in Challenging Issues in the Management of Chronic Hepatitis B Virus, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

HBV is most prevalent viral infection worldwide. Recent advances in HBV virology epidemiology and management are of utmost importance particularly during this time when HCV is taking the front row in discussion and research. However, there's an increased interest in management of HBV in special populations, which is covered in this issue. The authors also explore drugs in the pipeline as well as new approaches for achieving long-term viral suppression and possibly cure.

This issue offers the latest information regarding the transmission of hepatitis viruses in various healthcare settings. It delves with a very timely and interesting patient safety subject that specifically targets healthcare professionals, gastroenterologists, hepatologists, oncologists, dentists and all healthcare workers to adopt and share a variety of best practices to prevent this adverse event. Well known faculty in liver disease, infection control as well as a medical practice in a legal setting have been assembled to produce a comprehensive and concise edition that highlights the latest information regarding hepatitis B and C transmission in healthcare. It aims to provide an overview on the molecular epidemiology, the outbreak reports, the transmission in hemodialysis, endoscopy, dental, oncology, management, legal aspects and the infection prevention measures to reduce the risk of needless exposure of patients to these blood borne pathogens.

The Guest Editors have assembled top international experts to present clinical reviews on the most current data being utilized in the diagnosis, treatment, and management of HBV. In fact, the most recent EASL meeting fndings are included in many of the articles. Special focus is given to Results of Treatment of Chronic Hepatitis B with Pegylated Interferon; Impact of Therapy on the Long Term Outcome of Chronic Hepatitis B; HBsAg Quantification: Clinical; HBV Infection and Hepatocellular Carcinoma; HIV-HBV Co-Infection: An Update; Hepatitis Delta: The Rediscovery; and Treatment of Patients with HBV Related Decompensated Cirrhosis and Liver Transplanted Patients.

Hepatitis B continues to be a worldwide public health problem of major proportions, with over 10% of people in heavily populated endemic areas being chronic carriers of the virus. Enormous strides have been made in understanding the biology of HBV and in management. Overwhelming evidence demonstrates that long-term suppression of viral replication may prevent the dreaded long-term outcomes of this disease. Increasing numbers of drugs that can achieve this goal, without the high risk of emergent viral resistance that characterized treatment as recently as 5 years ago, are available and more will follow, but controversies abound about the most effective manner in which to use these agents and about which patients should be treated. Many experts believe we are moving into an era in which the spectrum of patients who we consider treatment candidates is expanding. A volume on our present understanding about the biology and immunology of HBV, along with a critical analysis of the complex therapeutic issues is most timely.

In this issue of Clinics in Liver Disease, guest editor Robert G. Gish brings his considerable expertise to the topic of Hepatitis B and Hepatitis D. The articles provide state-of-the-art clinical summaries of the advances in Hepatitis B and D, with emphasis on HBV viro-immunology, novel assays, new targets, and tests for HBV and HDV, and more. Contains 13 relevant, practice-oriented topics including Novel Assays to Solve the Clinical and Scientific Challenges of Chronic Hepatitis B; Maternal-to-Child Transmission of Hepatitis B Virus and Hepatitis Delta Virus; Triple Threat: HDV, HBV, HIV Coinfection; Targeting Hepatitis B Virus DNA Using Designer Gene Editors; and more. Provides in-depth clinical reviews on Hepatitis B and D, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Clinics in Liver Disease, guest editor Dr. Steven L. Flamm brings his considerable expertise to the topic of Updates in Consultations in Liver Disease. Many disease entities are uncommon and complicated in scope, and liver disease may occur in the setting of other chronic medical conditions and involve other organ systems. In this issue, top experts provide a up-to-date framework for approaching consultation for common liver-related problems for the gastroenterology and hepatology practitioner. Contains 12 practice-oriented topics including clinical pearls in evaluation and treatment of patients with liver disease; evaluation of patients with markedly elevated liver enzymes; evaluation of liver disease in pregnancy; COVID and implications on the liver; and more. Provides in-depth clinical reviews on consultations in liver disease, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.