Instructs Vose to always notify General [Henry] Jackson beforehand if he intends to draw money. Notes both he and Jackson need to know the amount and purpose of the draw. Informs Vose he plans on visiting St. George, Maine in May and expects the house (likely Montpelier) to be completed. Notes a number of fruit trees are being shipped to Vose and provides planting instructions for the trees. Also mentions his desire to have the ice house completed and stocked. Sends his love to Vose's family. The edge on the first page and the upper right corner on the last page of the letter is damaged causing minor text loss.

Informs Knox he was unable to secure a price for ground on the Mill River in Maine. Notes the owner says he will have a referral for the grounds upon Knox's arrival. Also mentions the owner was pleased about Knox's idea of building some mills. Discusses a land deal between Knox and another gentleman named Dorton Dodge. The land is likely located in Maine. Updates Knox on the construction of Knox's house (possibly Montpelier). Informs Knox Mr. Ebenezer Dunton will not begin building the ice house until next year. Discusses his family and wishes Knox's family well. Free stamped on address leaf with no signature.

Gives instructions for his house being built (Montpelier). References fruit trees being delivered and provides detailed instructions on where and how they should be planted. Says Colonel John Tyler might assist Vose with the planting. Mentions having an icehouse built.

Discusses furniture and stores and also gives Vose directions regarding the placement of rooms and goods for the house that he (Knox) is building. Pages are severely water damaged with very blurry writing.

Says the duties of his office and a recent illness have kept him from writing. Says it is his firm determination to be with him in June or July. Says as the house cannot be built for occupation this season, I would prefer that the digging of the cellars should be defered [sic] until my arrival, as he would like to pick the spot himself. Wants the stone and brick delivered to the place you should judge near the spot. Will speedily send a plan to Henry Jackson and will tell him to collect workmen. Says there will not be any difficulty as he recently purchased the patent from the Winslows. Says the bearer of this letter, Captain John Hills, will be surveying the townships in the patent and make a map of the whole. Says Hills is a capital draughtsman. Wants to bring his wife and children, but does not think he can get appropriate accommodations for them.

Writes his mason regarding the construction of his house (his future estate, Montpelier, in Maine). Requests Mr. [Henry] Simpson to provide General [Henry] Jackson with an estimate of the supplies that will be needed. Reminds him he wants a well built house, but also desires it to be plain and not made of expensive carvings or ornaments. Informs Mr. Simpson he will not be present during the beginning of construction and is relying on his expertise and reputation. Allows for him to choose which workmen to hire but insists all agreements are made in writing. Gives detailed instructions on the size and style of each room, including the windows and doors. This includes the foundation of the house, the cellar, basement, flooring, parlor, chamber story, oval room, and various other rooms. Discusses moving the house further north and reminds him to show this letter to Captain [Thomas] Vose and to listen to Vose's instructions.