Heart Regeneration: Stem Cells And Beyond
Title | Heart Regeneration: Stem Cells And Beyond PDF eBook |
Author | Felix B Engel |
Publisher | World Scientific |
Pages | 393 |
Release | 2012-03-22 |
Genre | Medical |
ISBN | 9814465259 |
Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury.This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.
Regeneration: Stem Cells and Beyond
Title | Regeneration: Stem Cells and Beyond PDF eBook |
Author | Ellen Heber-Katz |
Publisher | Springer Science & Business Media |
Pages | 212 |
Release | 2003-09-16 |
Genre | Science |
ISBN | 9783540022381 |
In this issue of Current Topics in Microbiology and Immunology the authors present a unique range of examples of the regenerative response and the role of stem cells from the amphibian to human. It seems that all roads lead to cells that have the plasticity to become something else, not only in the amphibian but also in the mammal.
Stem Cells and Cardiac Regeneration
Title | Stem Cells and Cardiac Regeneration PDF eBook |
Author | Rosalinda Madonna |
Publisher | Springer |
Pages | 219 |
Release | 2015-12-18 |
Genre | Science |
ISBN | 3319254278 |
This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic aspects of stem cells such as definitions, isolation criteria and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue specific progenitor and stem cells. In the following section, the text examines the role of critical regulators of stem cell differentiation in myocardial regeneration, that include circadian rhythyms, microRNAs, epigenetics, microvescicles, and exosomes. The text concludes with a review of the use of stem/progenitor cells in cardiac regeneration and discuss current controversies, unresolved issues, challenges, and future directions. Stem Cells and Cardiac Regeneration is addressed to a wide audience consisting of cardiologists, clinicians, and research scientists, who will learn new concepts in cardiovascular regeneration and repair with special focus on molecular mechanisms and therapeutic potential for cardiovascular regeneration.
Cardiac regeneration and angiogenesis beyond stem cell research
Title | Cardiac regeneration and angiogenesis beyond stem cell research PDF eBook |
Author | Adriana C. Gittenberger-de Groot |
Publisher | |
Pages | 32 |
Release | 2007 |
Genre | |
ISBN |
Biomaterials for Cardiac Regeneration
Title | Biomaterials for Cardiac Regeneration PDF eBook |
Author | Erik J. Suuronen |
Publisher | Springer |
Pages | 333 |
Release | 2014-11-12 |
Genre | Technology & Engineering |
ISBN | 3319109723 |
This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications.
Cardiac Regeneration and Angiogenesis Beyond Stem Cell Research
Title | Cardiac Regeneration and Angiogenesis Beyond Stem Cell Research PDF eBook |
Author | Adriana Gittenberger-de Groot |
Publisher | |
Pages | 32 |
Release | 2007 |
Genre | |
ISBN |
Stem Cells and Myocardial Regeneration
Title | Stem Cells and Myocardial Regeneration PDF eBook |
Author | Marc S. Penn |
Publisher | Springer Science & Business Media |
Pages | 314 |
Release | 2007-11-06 |
Genre | Medical |
ISBN | 1597452726 |
Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.