The history of Prentiss County, Mississippi, including the people and families, buildings, businesses, churches, organizations, schools and and sports.

Family history and genealogical information about the descendants of John O'Gallaher (or Gallaher) and Margaret (surname unknown). They lived in County Donegal, Ireland. Three of their five children immigrated to America ca. 1758 and settled in Pennsylvania. Emphasis in given to their son James who immigrated to America and first lived in Mifflin Station, Pennsylvania. James later settled in the state of Tennessee. Descendants of John and Margaret Gallaher lived primarily in Pennsylvania, Tennessee, Texas, Missouri and Oklahoma.

The siblings, Samuel (b. 1783), James (b. 1787) and Martha (b. 1798) Perkins, are found first in Anson County, North Carolina in the early 1800s. Their ancestors probably immigrated to the Carolinas during colonial times. By 1815 the three families were in Tennessee. Descendants are in Mississippi and Texas.