Handbook of Ion Channels

Handbook of Ion Channels
Title Handbook of Ion Channels PDF eBook
Author Jie Zheng
Publisher CRC Press
Pages 682
Release 2015-02-25
Genre Medical
ISBN 1466551429

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The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Ion Channels

Ion Channels
Title Ion Channels PDF eBook
Author Nikita Gamper
Publisher Humana Press
Pages 456
Release 2016-05-01
Genre Science
ISBN 9781493960095

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This Methods in Molecular Biology book offers strategies and protocols for studying a large group of proteins that form ionic channels in the plasma membrane and intracellular membranes of cells. Includes step-by-step protocols, materials lists, tips and more."

Ionic Channels of Excitable Membranes

Ionic Channels of Excitable Membranes
Title Ionic Channels of Excitable Membranes PDF eBook
Author Bertil Hille
Publisher Sinauer Associates, Incorporated
Pages 638
Release 1992
Genre Medical
ISBN

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This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.

Voltage-gated Sodium Channels: Structure, Function and Channelopathies

Voltage-gated Sodium Channels: Structure, Function and Channelopathies
Title Voltage-gated Sodium Channels: Structure, Function and Channelopathies PDF eBook
Author Mohamed Chahine
Publisher Springer
Pages 448
Release 2018-06-04
Genre Medical
ISBN 3319902849

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This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Pharmacology of Potassium Channels

Pharmacology of Potassium Channels
Title Pharmacology of Potassium Channels PDF eBook
Author Nikita Gamper
Publisher Springer Nature
Pages 546
Release 2021-09-27
Genre Medical
ISBN 3030840522

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The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.

Mammalian Transient Receptor Potential (TRP) Cation Channels

Mammalian Transient Receptor Potential (TRP) Cation Channels
Title Mammalian Transient Receptor Potential (TRP) Cation Channels PDF eBook
Author Bernd Nilius
Publisher Springer
Pages 569
Release 2014-06-24
Genre Medical
ISBN 331905161X

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​In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.

Ion Channel Pharmacology

Ion Channel Pharmacology
Title Ion Channel Pharmacology PDF eBook
Author Bernat Soria
Publisher
Pages 498
Release 1998
Genre Medical
ISBN

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The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.