This two-volume handbook, prepared by Editors involved in an EU validation project on speciation, provides comprehensive coverage of the sample preparation methods and analytical techniques utilised for speciation of different elements in environmental, food, and clinical samples. Handbook of Elemental Speciation I - Techniques and Methodology brings together a collection of chapters covering different aspects of procedures for speciation analysis at the different levels starting from sample collection and storage, through sample preparation approaches to render the species chromatographable, principles of separation techniques used in speciation analysis, to the element specific detection. Also covers quality assurance and risk assessment, and speciation-relevant legislation. Handbook of Elemental Speciation II - Species in the Environment, Food, Medicine and Occupational Health provides a comprehensive, cross-disciplinary presentation of the analytical techniques involved in speciation. * Comprehensive coverage of key elements and compounds in situ * Addresses the analysis and impact of these elements and compounds, e.g. arsenic, lead, copper, iron, halogens, etc., in food, the environment, clinical and occupational health * Detailed methodology and data are reported, as well as regulatory limits * Includes general introduction on the impact in these key areas

Written by an internationally recognized group of editors and contributors, Handbook of Elemental Speciation, Volume 2 provides a comprehensive, cross-disciplinary presentation of the analytical techniques involved in speciation. Comprehensive coverage of key elements and compounds in situ Addresses the analysis and impact of these elements and compounds, e.g. arsenic, lead, copper, iron, halogens, etc., in food, the environment, clinical and occupational health Detailed methodology and data are reported, as well as regulatory limits Includes general introduction on the impact in these key areas

Written by an internationally recognized group of editors and contributors, Handbook of Elemental Speciation, Volume 2 provides a comprehensive, cross-disciplinary presentation of the analytical techniques involved in speciation. Comprehensive coverage of key elements and compounds in situ Addresses the analysis and impact of these elements and compounds, e.g. arsenic, lead, copper, iron, halogens, etc., in food, the environment, clinical and occupational health Detailed methodology and data are reported, as well as regulatory limits Includes general introduction on the impact in these key areas

This international collection of chapters comprehensively covers different aspects of procedures for speciation analysis at all levels starting from sample collection and storage, through sample preparation approaches to render the species chromatographable, principles of separation techniques used in speciation analysis, to the element specific detection. International renowned editors and contributors Includes coverage of electrochemical methods, biosensors for metal ions, radioisotope techniques and direct solid speciation techniques Provides information on quality assurance and risk assessment, and speciation-relevant legislation Each chapter is a stand-alone reference covering a given facet of elemental speciation analysis written by an expert in a given field with the volume as a whole providing an excellent introductory text and reference handbook.

Designed as a first-stop reference for researchers and professionals in toxicology, pharmacology and medicine, this handbook is the very first to tie together the knowledge from many disciplines that has so far been available only from widely dispersed sources in the primary literature. As such, it presents the complete picture on what is currently known about endogenous toxins, including their generation, mode of action, resulting disease condition, and available countermeasures. Clearly divided into four parts, the first systematically covers important toxic molecule species, including metabolic intermediates and reactive oxygen species. The second discusses the role of genetically determined metabolic malfunctions, such as galactosemia, hyperlipidemia, porphyria, hemochromatosis and related conditions, while part three looks at acquired and chronic diseases caused or exacerbated by endogenous toxins, such as hepatic injury, asthma, rheumatism, colorectal cancer, reperfusion diseases, neurodegneration and aging. The final part reviews currents strategies to control and minimize the effect of endogenous toxins, either by nutritional or pharmacological interventions. With its complete coverage integrating molecular and systemic aspects from the biochemical basis to human disease conditions, this comprehensive reference will appeal to a broad target group of toxicologists, biochemists, nutrition specialists and physicians.