Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

During his lifetime, W.E. Blatz was so much occupied with the development of the University of Toronto’s Institute of Child Study that he was able to devote little time to writing. This is his first book to appear in twenty-one years, and his first complete exposition of his famous Theory of Security. The Theory of Security is radically different from the theories promulgated by Freudian psychologists. Whereas Freudian personality theory is based on the notion of “unconscious,” an entity that is only indirectly observable, the Theory of Security derives from the observation of the conscious state in all its manifestations. Dr. Blatz thus makes use of both empirical observations and the results of introspection, and, as might be expected, some of his conclusions run counter to those reached in much current psychological discussion. But proof of the forcible influence of the theory and its author may be found in the impressive number of books and articles already published by Dr. Blatz’s associates at the Institute of Child Study, applying the theory to the practical problems of psychological observation and therapy. It is fitting that the man whose work has generated so much fruitful research by others in this field should at last have set down in book form the fundamental principles that guided them.