Pharmaceutical Extrusion Technology is the only resource to provide in-depth descriptions and analyses of the key parameters of extruders and extrusion processes. The book highlights the applicability of melt extrusion in pharmaceutical drug development and product manufacturing, including controlled release, dissolution rate and bioavailability enhancement, and granulation technology. It brings together the technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements and details extruder hardware and controls, process definition and troubleshooting of single and twin screw extrusion processes, and more.

Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies

Granulation technology is important to the manufacturing of many bioproducts, such as detergent enzymes (biologically-derived products) and pharmaceuticals (bioactive products). This book describes the granulation of bioproducts through traditional approaches, such as fluidized bed granulation, spray drying, high-shear granulation and extrusion-spheronization, in addition to the application of newer approaches such as microencapsulation and liquid phase granulation. Freeze drying is also covered, which is the preferred mode for producing granular starter cultures used in the dairy industry. In addition to discussions regarding the full spectrum of suitable granulation processes, post-granulation steps such as drying (for wet processes) and coating are explained. The slant of the book is practical, which is borne out by chapters regarding the various industrial processes used to manufacture granular detergent enzymes and immobilized glucose isomerase and the selection of proper granulation processes for specific applications. Granulation Technology for Bioproducts is an important book for all bioproduct processing engineers.

Granulation provides a complete and comprehensive introduction on the state-of-the-art of granulation and how it can be applied both in an academic context and from an industrial perspective. Coupling science and engineering practices it covers differing length scales from the sub-granule level through behaviour through single granules, to bulk granule behaviour and equipment design. With special focus on a wide range of industrially relevant areas from fertilizer production, through to pharmaceuticals. Experimental data is complemented by mathematical modelling in this emerging field, allowing for a greater understanding of the basis of particle products and this important industry sector.Four themes run through the book: 1. The Macro Scale processing for Granulation – including up to date descriptions of the methods used for granulation and how they come about and how to monitor – on-line these changes.2. The Applications of granulation from an industrial perspective, with current descriptive roles and how they are undertaken with relevance to industry, and effective properties.3. Mechanistic descriptions of granulation and the different rate processes occurring within the granulator. This includes methods of modelling the process using Population – Balance Equations, and Multi-level Computational Fluid Dynamics Models.4. The Micro Scale: Granules and Smaller, looking at single granules and there interactions and modelling, while also considering the structure of granules and their constituent liquid bridges.* Covers a wide range of subjects and industrial applications* Provides an understanding of current issues for industrial and academic environments* Allows the reader an understanding of the science behind engineered granulation processes

As a result of developments in biotechnology, bioengineering, and related sciences, processing of bio-materials and bioproducts has become an area of strategic importance. Written in a textbook style, this book attempts to bring together both the theory and practice of thermal processing of bio-materials. The authors describe the principal techniques such as freezing, chilling, membrane concentration, evaporation, drying, and sterilization and their own research experiences, including degradation of thermo and xerolabile bio- products.

Proceedings of the Thirteenth Annual Meeting of the Japanese Association for Animal Cell Technology (JAACT), Fukuoka-Karatsu, November 16-21, 2000

This volume, Fluidization, Solids Handling, and Processing, is the first of a series of volumes on "Particle Technology". Particles are important products of chemical process industries spanning the basic and specialty chemicals, agricultural products, pharmaceuticals, paints, dyestuffs and pigments, cement, ceramics, and electronic materials. Solids handling and processing technologies are thus essential to the operation and competitiveness of these industries. Fluidization technology is employed not only in chemical production, it also is applied in coal gasification and combustion for power generation, mineral processing, food processing, soil washing and other related waste treatment, environmental remediation, and resource recovery processes. The FCC (Fluid Catalytic Cracking) technology commonly employed in the modern petroleum refineries is also based on fluidization principles.