Genomic Surveillance and Pandemic Preparedness
Title | Genomic Surveillance and Pandemic Preparedness PDF eBook |
Author | Rajesh Pandey |
Publisher | Elsevier |
Pages | 428 |
Release | 2023-06-29 |
Genre | Science |
ISBN | 0443187681 |
Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inference—moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness. Highlights different aspects of genomic surveillance, from theory to implementation to inferences Covers a broad range of infectious diseases, with emphasis on recent COVID-19 studies Shares methods and approaches for sequencing-based pathogen detection, diagnostics, and surveillance Facilitates international collaboration in drug and vaccine development
Considerations for developing a national genomic surveillance strategy or action plan for pathogens with pandemic and epidemic potential
Title | Considerations for developing a national genomic surveillance strategy or action plan for pathogens with pandemic and epidemic potential PDF eBook |
Author | World Health Organization |
Publisher | World Health Organization |
Pages | 28 |
Release | 2023-08-18 |
Genre | Medical |
ISBN | 9240076565 |
Policy considerations to strengthen genomic surveillance for pathogens with pandemic and epidemic potential is a support tool that provides key consideration and a proposed stepwise approach for countries to develop a national genomic surveillance strategy or action plan for pathogens with pandemic and epidemic potential. This document is intended for use by all stakeholders at the national and subnational level relevant to the development and implementation of the strategy or action plan, including health authorities, One Health partners, donors, public health officers, academia, the private sector and laboratory specialists.
Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022–2032
Title | Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022–2032 PDF eBook |
Author | World Health Organization |
Publisher | World Health Organization |
Pages | 58 |
Release | 2023-12-04 |
Genre | Medical |
ISBN | 9240084770 |
Global genomic surveillance strategy for pathogens with pandemic and epidemic potential, 2022-2032
Title | Global genomic surveillance strategy for pathogens with pandemic and epidemic potential, 2022-2032 PDF eBook |
Author | |
Publisher | World Health Organization |
Pages | 32 |
Release | 2022-03-23 |
Genre | Medical |
ISBN | 9240046976 |
The Global Genomic Surveillance Strategy for Pathogens with Pandemic and Epidemic Potential 2022-2032 provides a high-level unifying framework to leverage existing capacities, address barriers and strengthen the use of genomic surveillance in the detection, monitoring and response to public health threats. Genomic surveillance is part of the broader surveillance and laboratory system, and its implementation should reinforce end-to-end capacities including sample collection, diagnostics, data sharing and analysis. The strategy aims to facilitate the connectivity between different disease control programs and surveillance networks. This interoperability will strengthen the cross-cutting essential public health laboratory functions underpinning genomics holistically. The strategy articulates the overarching goal, objectives and strategic actions needed. These are dependent on commitments from countries, partners and WHO for their implementation.
An Appeal for Strengthening Genomic Pathogen Surveillance to Improve Pandemic Preparedness and Infection Prevention: the German Perspective
Title | An Appeal for Strengthening Genomic Pathogen Surveillance to Improve Pandemic Preparedness and Infection Prevention: the German Perspective PDF eBook |
Author | Bernd Salzberger |
Publisher | |
Pages | 0 |
Release | 2023 |
Genre | |
ISBN |
Abstract: The SARS-CoV-2 pandemic has highlighted the importance of viable infection surveillance and the relevant infrastructure. From a German perspective, an integral part of this infrastructure, genomic pathogen sequencing, was at best fragmentary and stretched to its limits due to the lack or inefficient use of equipment, human resources, data management and coordination. The experience in other countries has shown that the rate of sequenced positive samples and linkage of genomic and epidemiological data (person, place, time) represent important factors for a successful application of genomic pathogen surveillance. Planning, establishing and consistently supporting adequate structures for genomic pathogen surveillance will be crucial to identify and combat future pandemics as well as other challenges in infectious diseases such as multi-drug resistant bacteria and healthcare-associated infections. Therefore, the authors propose a multifaceted and coordinated process for the definition of procedural, legal and technical standards for comprehensive genomic pathogen surveillance in Germany, covering the areas of genomic sequencing, data collection and data linkage, as well as target pathogens. A comparative analysis of the structures established in Germany and in other countries is applied. This proposal aims to better tackle epi- and pandemics to come and take action from the "lessons learned" from the SARS-CoV-2 pandemic
Future surveillance for epidemic and pandemic diseases
Title | Future surveillance for epidemic and pandemic diseases PDF eBook |
Author | World Health Organization |
Publisher | World Health Organization |
Pages | 59 |
Release | 2023-12-11 |
Genre | Medical |
ISBN | 9240080953 |
Surveillance is a pillar of the public health response to epidemics and pandemics. Yet, gaps in surveillance, from the local to the global, continue to leave the world vulnerable to infectious hazards. To address these vulnerabilities, the health emergency preparedness, response, and resilience (HEPR) architecture calls for a new approach to future surveillance - collaborative surveillance - that aligns traditional tactics with new initiatives to safeguard health for all. This report reflects the input and advice on future surveillance of leading experts with different skills, worldviews and experiences who share a commitment to better prepare for future infectious hazards. It charts a course towards future surveillance and collaborative action.
Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022-2032
Title | Global genomic surveillance strategy for pathogens with pandemic and epidemic potential 2022-2032 PDF eBook |
Author | World Health Organization |
Publisher | World Health Organization |
Pages | 26 |
Release | 2023-05-01 |
Genre | Medical |
ISBN | 9240057404 |
The Global Genomic Surveillance Strategy for Pathogens with Pandemic and Epidemic Potential 2022-2032 provides a high-level unifying framework to leverage existing capacities, address barriers and strengthen the use of genomic surveillance in the detection, monitoring and response to public health threats. Genomic surveillance is part of the broader surveillance and laboratory system, and its implementation should reinforce end-to-end capacities including sample collection, diagnostics, data sharing and analysis. The strategy aims to facilitate the connectivity between different disease control programs and surveillance networks. This interoperability will strengthen the cross-cutting essential public health laboratory functions underpinning genomics holistically. The strategy articulates the overarching goal, objectives and strategic actions needed. These are dependent on commitments from countries, partners and WHO for their implementation.