Biodefense in the Age of Synthetic Biology

Biodefense in the Age of Synthetic Biology
Title Biodefense in the Age of Synthetic Biology PDF eBook
Author National Academies of Sciences, Engineering, and Medicine
Publisher National Academies Press
Pages 189
Release 2019-01-05
Genre Technology & Engineering
ISBN 0309465184

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Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Genome Editing and Biological Weapons

Genome Editing and Biological Weapons
Title Genome Editing and Biological Weapons PDF eBook
Author Katherine Paris
Publisher Springer Nature
Pages 281
Release 2022-12-15
Genre Science
ISBN 3031218205

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This monograph introduces current genome editing technologies—clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)—and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases—including CRISPR, TALEN, and ZFN—allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.

CRISPR-Cas Systems

CRISPR-Cas Systems
Title CRISPR-Cas Systems PDF eBook
Author Rodolphe Barrangou
Publisher Springer Science & Business Media
Pages 300
Release 2012-12-13
Genre Science
ISBN 364234657X

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CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Ethics Dumping

Ethics Dumping
Title Ethics Dumping PDF eBook
Author Doris Schroeder
Publisher Springer
Pages 144
Release 2017-12-04
Genre Philosophy
ISBN 3319647318

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This open access book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training.

The Soviet Biological Weapons Program

The Soviet Biological Weapons Program
Title The Soviet Biological Weapons Program PDF eBook
Author Milton Leitenberg
Publisher Harvard University Press
Pages 956
Release 2012-06-29
Genre History
ISBN 0674065263

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This is the first attempt to understand the full scope of the USSR’s offensive biological weapons research, from inception in the 1920s. Gorbachev tried to end the program, but the U.S. and U.K. never obtained clear evidence that he succeeded, raising the question whether the means for waging biological warfare could be present in Russia today.

Biotechnology, Weapons and Humanity

Biotechnology, Weapons and Humanity
Title Biotechnology, Weapons and Humanity PDF eBook
Author British Medical Association
Publisher CRC Press
Pages 188
Release 1999-01-18
Genre Political Science
ISBN 9789057024597

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Biotechnology, Weapons and Humanity traces the historical development of biological weapons and considers the role of health care professionals, scientists, governments, and international agencies in limiting and managing the effects of new biological weapons. In particular, the strengths and weaknesses of the Biological and Toxin Weapons Convention are examined, and steps that can be taken to minimize the risk of the proliferation of weapons. This report considers whether new biological weapons, made possible by the mapping of the human genome, could be incorporated into the arsenals of states and terrorist organizations. How might the revolution in biotechnology be used to attack the genetic constitution of a national or ethnic group, or enhance the virulence of organizations hostile to human health?

Bio-Imperialism

Bio-Imperialism
Title Bio-Imperialism PDF eBook
Author Gwen Shuni D'Arcangelis
Publisher Rutgers University Press
Pages 117
Release 2020-12-18
Genre History
ISBN 1978815166

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Bio-Imperialism focuses on an understudied dimension of the war on terror: the fight against bioterrorism. This component of the war enlisted the biosciences and public health fields to build up the U.S. biodefense industry and U.S. global disease control. The book argues that U.S. imperial ambitions drove these shifts in focus, aided by gendered and racialized discourses on terrorism, disease, and science. These narratives helped rationalize American research expansion into dangerous germs and bioweapons in the name of biodefense and bolstered the U.S. rationale for increased interference in the disease control decisions of Global South nations. Bio-Imperialism is a sobering look at how the war on terror impacted the world in ways that we are only just starting to grapple with.