This issue describes in detail the most current thinking on the way genes affect and determine sleep patterns, behaviors, disorders and needs. Sleep researchers continue to study genetic markers that may someday lead to a personalized approach to treatment of sleep disorders. The genetics of restless legs syndrome, narcolepsy, circadian rhythm disorders, obstructive sleep apnea, parasomnias, and insomnia are discussed. A solid understanding of the role genetics and molecular biology play in sleep will aid clinicians in diagnosing and treating these disorders, as well as advising their patients.

Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Proceedings of a Japanese-German International Symposium held in Erfurt, Germany, October 9-10, 1996

This issue of Sleep Medicine Clinics, Guest Edited by Teofilo Lee-Chiong MD, will focus on Biology of Sleep, with article topics including: Neurology of Sleep; Normal Sleep and Circadian Rhythms: Neurobiologic Mechanisms Underlying Sleep and Wakefulness; Physiology of Sleep Disordered Breathing; Evaluation of the Patient Who Has Sleep Complaints: A Case-Based Method Using the Sleep Process Matrix; Sleep States,Memory Processing, and Dreams; Neurobiologic Mechanisms in Chronic Insomnia; Sleep Behavior and Sleep Regulation from Infancy through Adolescence: Normative Aspects; Biological Timekeeping; Neurologic Basis of Sleep Breathing Disorders; Genetics of Sleep Timing, Duration, and Homeostasis in Humans; Sleep in Normal Aging; Modulation of Endocrine Function by Sleep-Wake Homeostasis and Circadian Rhythmicity; Cardiac Activity and Sympathovagal Balance During Sleep; Sleep and Cytokines; Neuropharmacology of Sleep and Wakefulness; Staging Sleep; Respiratory Physiology During Sleep; and Cyclic Alternating Pattern (CAP), Sleep Disordered Breathing, and Automatic Analysis.

This issue comprises two parts. The first part examines pharmacology of drug classes and effects on the sleep--wake processes. The second part focuses on therapeutics for various sleep disorders. In the first part, basic neuropharmacology of sleep-wake states is discussed. Other articles review hypnotics, allergy and cardiovascular drugs, anti-convulsant drugs, anti-depressant and anti-psychotic drugs, and stimulants. The second part focuses on pharmacology for specific sleep disorders: primary insomnia, co-morbid insomnia, sleep-related breathing disorders, narcolepsy and disorders of daytime sleepiness, movement disroders, parasomnias, and circadian rhythm disorders.

This issue of Sleep Medicine Clinics is edited by Dr.Ahmed BaHammam and focuses on Hypersomnia. Article topics include: Hypersomnia: neurobiological basis; Narcolepsy Immunogenetics: Where is the Evidence?; Genetic markers of sleepiness; Autonomic function instabilities in Narcolepsy; Epidemiology of Excessive Daytime Sleepiness; Evaluation of the sleepy patient: differential diagnosis; Subjective and objective assessment of hypersomnia; Sleepiness in Narcolepsy; Idiopathic hypersomnia; Sleep disordered breathing and excessive daytime sleepiness; Drug-induced excessive sleepiness; Kleine-Levin syndrome and recurrent hypersomnia; Behaviorally induced insufficient sleep syndrome: an underestimated cause of hypersomnia; Sleepiness in children; Sleepiness in Adolescents; Sleepiness in the elderly; Depression and Hypersomnia: a complex association; Neurodegenerative diseases and excessive sleepiness; Sleepiness and traffic safety; Pharmacological management of excessive daytime sleepiness; Non-pharmacological management of excessive daytime sleepiness.

Movement Disorders in Sleep, An Issue of Sleep Medicine Clinics, E-Book