This book is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Features: introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection; presents a brief evolutionary history of life from the primordial seas to the emergence of humans; describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans; reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building; discusses databases of genome sequences and related information, evolutionary distances, and population genomics; provides supplementary material at an associated website.

Biological evolution is the phenomenon concerning how species are born, are transformed or disappear over time. Its study relies on sophisticated methods that involve both mathematical modeling of the biological processes at play and the design of efficient algorithms to fit these models to genetic and morphological data. Models and Methods for Biological Evolution outlines the main methods to study evolution and provides a broad overview illustrating the variety of formal approaches used, notably including combinatorial optimization, stochastic models and statistical inference techniques. Some of the most relevant applications of these methods are detailed, concerning, for example, the study of migratory events of ancient human populations or the progression of epidemics. This book should thus be of interest to applied mathematicians interested in central problems in biology, and to biologists eager to get a deeper understanding of widely used techniques of evolutionary data analysis.

Phylogenies, or evolutionary trees, are the basic structures necessary to think about and analyze differences between species. Statistical, computational, and algorithmic work in this field has been ongoing for four decades now, and there have been great advances in understanding. Yet no book has summarized this work. Inferring Phylogenies does just that in a single, compact volume. Phylogenies are inferred with various kinds of data. This book concentrates on some of the central ones: discretely coded characters, molecular sequences, gene frequencies, and quantitative traits. Also covered are restriction sites, RAPDs, and microsatellites.

The NATO Advanced Study Institute on Numerical Taxonomy took place on the 4th - 16th of July, 1982, at the Kur- und Kongresshotel Residenz in Bad Windsheim, Federal Republic of Germany. This volume is the proceedings of that meeting, and contains papers by over two-thirds of the participants in the Institute. Numerical taxonomy has been attracting increased attention from systematists and evolutionary biologists. It is an area which has been marked by debate and conflict, sometimes bitter. Happily, this meeting took place in an atmosphere of "GemUtlichkeit", though scarcely of unanimity. I believe that these papers will show that there is an increased understanding by each taxonomic school of each others' positions. This augurs a period in which the debates become more concrete and specific. Let us hope that they take place in a scientific atmosphere which has occasionally been lacking in the past. Since the order of presentation of papers in the meeting was affected by time constraints, I have taken the liberty of rearranging them into a more coherent subject ordering. The first group of papers, taken from the opening and closing days of the meeting, debate philosophies of classification. The next two sections have papers on congruence, clustering and ordination. A notable concern of these participants is the comparison and testing of classifications. This has been missing from many previous discussions of numerical classification.

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