This Clinical Practice Guideline presents recommendations and summarizes the supporting evidence for pressure ulcer prevention and treatment. The first edition was developed as a four year collaboration between the National Pressure Ulcer Advisory Panel (NPUAP) and the European Pressure Ulcer Advisory Panel (EPUAP). In this second edition of the guideline, the Pan Pacific Pressure Injury Alliance (PPPIA) has joined the NPUAP and EPUAP. This edition of the guideline has been developed over a two year period to provide an updated review of the research literature, extend the scope of the guideline and produce recommendations that reflect the most recent evidence. It provides a detailed analysis and discussion of available research, critical evaluation of the assumptions and knowledge in the field, recommendations for clinical practice, a description of the methodology used to develop the guideline and acknowledgements of the 113 experts formally involved in the development process.

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

This book, dedicated to Roger Penrose, is a second, mathematically oriented course in general relativity. It contains extensive references and occasional excursions in the history and philosophy of gravity, including a relatively lengthy historical introduction. The book is intended for all students of general relativity of any age and orientation who have a background including at least first courses in special and general relativity, differential geometry, and topology. The material is developed in such a way that through the last two chapters the reader may acquire a taste of the modern mathematical study of black holes initiated by Penrose, Hawking, and others, as further influenced by the initial-value or PDE approach to general relativity. Successful readers might be able to begin reading research papers on black holes, especially in mathematical physics and in the philosophy of physics. The chapters are: Historical introduction, General differential geometry, Metric differential geometry, Curvature, Geodesics and causal structure, The singularity theorems of Hawking and Penrose, The Einstein equations, The 3+1 split of space-time, Black holes I: Exact solutions, and Black holes II: General theory. These are followed by two appendices containing background on Lie groups, Lie algebras, & constant curvature, and on Formal PDE theory.

As clinical interest in overhead athletic injuries is on the upswing, so is greater interest in the factors for performance and injury risk in throwing and other overhead motion. This practical, case-based text is divided into two sections and will present the basic principles of overhead athletes followed by unique clinical case presentations describing different aspects of performance, injury and management in throwing and other overhead athletes. Part I discusses the mechanics and pathomechanics of the overhead motion, along with principles of evaluation, the physical exam, surgical management of both the shoulder and elbow, rehabilitation and return to play, injury risk modification, and the role of the scapula. Unique clinical cases comprise all of part II and follow a consistent format covering the history, exam, imaging, diagnosis and outcome of the chosen intervention. These cases illustrate a cross-section of sports and activities, from the baseball player to the swimmer, and a range of shoulder and elbow problems in pediatric and adult overhead athletes Providing a unique case-based approach to a growing hot topic, Mechanics, Pathomechanics and Injury in the Overhead Athlete is an ideal resource for orthopedic surgeons, sports medicine specialists, physiatrists, physical therapists, certified athletic trainers and allied medical professions treating active persons of all ages.

Human milk is uniquely tailored to meet infants’ specific nutritional requirements. However, it is more than just “milk”. This dynamic and bioactive fluid allows mother–infant signalling over lactation, guiding the infant in the developmental and physiological processes. It exerts protection and life-long biological effects, playing a crucial role in promoting healthy growth and optimal cognitive development. The latest scientific advances have provided insight into different components of human milk and their dynamic changes over time. However, the complexity of human milk composition and the synergistic mechanisms responsible for its beneficial health effects have not yet been unravelled. Filling this knowledge gap will shed light on the biology of the developing infant and will contribute to the optimization of infant feeding, particularly that of the most vulnerable infants. Greater understanding of human milk will also help in elucidating the best strategies for its storage and handling. The increasing knowledge on human milk’s bioactive compounds together with the rapidly-advancing technological achievements will greatly enhance their use as prophylactic or therapeutic agents. The current Special Issue aims to welcome original works and literature reviews further exploring the complexity of human milk composition, the mechanisms underlying the beneficial effects associated with breastfeeding, and the factors and determinants involved in lactation, including its promotion and support.