With collaboration of Dr. Alan Buchman, Consulting Editor, Dr. Perry J. Pickhardt has created a comprehensive issue of Gastroenterology Clinics that looks at imaging techniques for gastrointestinal diseases. Experts in their respective fields have contributed clinical reviews in the following areas: Evaluation of Dysphagia: The Role of Barium Fluoroscopy; CT and MR Small Bowel Enterography: Current Status and Future Trends; Radiologic Assessment of Gastrointestinal Bleeding; CT Colonography: Implementation for Screening; Rectal MR for Cancer Staging and Surveillance; Defecography (fluoro vs MR); Noninvasive Imaging Techniques for Staging Liver Fibrosis; HCC Screening: Comparison of US, CT, and MR Approaches; Pancreatic Cystic Lesions; Overview of biliary imaging; Splenomegaly: Clinico-Radiologic Approach to the Differential Diagnosis; MR for Non-Traumatic Acute Abdominal Pain: Comparison with CT and US; and PET/MR: Current Clinical Status and Future Prospects. Gastroenterologists will come away with the knowledge they need to understand the latest imaging modalities for diagnosis and assessment of gastrointestinal diseases and disorders.

In this issue of Gastroenterology Clinics, Guest Editors M. Nedim. N. Ince and David E. Elliott bring their considerable expertise to the topic of Gastrointestinal Infections. Top experts in the field cover key topics such as Candida esophagitis, Acute bacterial gastroenteritis, Clostridium difficile infection and antibiotic-associated diarrhea, and more. - Provides concise and comprehensive coverage of the issues physicians face every day. - Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field. - Contains 14 relevant, practice-oriented topics including Helicobacter pylori infection; Viral gastroenteritis in special patient populations; Rare causes of hepatitis; Postinfectious irritable bowel syndrome; and more.

The Guest Editors have put together a concise monograph on the latest advances in transplantation of the liver, intestine, and pancreas. Expert authors have written comprehensive reviews on the following topics: Living donor liver transplantation: Technical innovations; Liver transplantation for cholangiocarcinoma; Immunological monitoring to personalize immunosuppression after liver transplantation; Status of adult LDLT in US based on A2ALL; Pediatric liver transplantation; Modern treatment of fulminant liver failure; Intestinal failure and rehabilitation; Adult intestinal transplantation; Pediatric intestinal transplantation; Living donor intestinal transplantation; Endoscopic follow-up of intestinal transplant recipients; Multivisceral transplantation; Pancreas transplantation for DM1 and DM2; and Robotic pancreas transplantation. Readers will come away with the clinical information they need to stay current on issues surrounding gastrointestinal transplantations.

In consultation with Consulting Editor, Dr. Alan Buchman, Dr. Stanley J. Naides has put together a state-of the-art issue of the Gastroenterology Clinics of North America devoted to Laboratory Monitoring of Gastrointestinal and Hepatobiliary Disease. Clinical review articles from expert authors are specifically devoted to the following: Inborn Errors of Metabolism and the GI track; Primary Immunodeficiency and the gut; Liver fibrosis determination; IBD; Autoimmune liver disease diagnosis and classification; Laboratory Diagnosis of Viral hepatitis; IgG4-RD with Emphasis on its GI Manifestation; Bowel Microbiome in Health and Disease; AAV System; and Celiac Disease. Readers will come away with the latest information they need to diagnose and monitor patients with gastrointestinal and hepatobiliary disease.

This issue of Gastroenterology Clinics of North America is all about acute upper GI bleeding and is divided into two distinct sections: section I is devoted to nonvariceal upper GI bleeding and section II is devoted to variceal upper GI bleeding. Acute nonvariceal upper GI bleeding may originate from the esophagus, stomach, or duodenum, essentially anywhere proximal to the Ligament of Treitz. In Section I, Dr Gianluca Rotondano, Hospital Maresca, Torre del Greco, Italy, begins with a review of the epidemiology and diagnosis of acute nonvariceal upper GI bleeding. We then turn to patient presentation, risk stratification, and how to initially medically manage these bleeding patients. I am pleased to have one of our emergency medicine colleagues, Dr Andrew Meltzer, Department of Emergency Medicine, George Washington University, contribute this important article and provide a unique viewpoint from the emergency department where most of these patients initially present. As we all know, endoscopic hemostasis is the accepted standard of care for patients with acute nonvariceal upper GI bleeding. Moreover, peptic ulcer bleeding is the most common nonvariceal cause of acute upper GI bleeding; thus, Drs Yidan Lu, Yen-I Chen, and Alan Barkun from McGill University, Montreal, Canada, provide an in-depth review of the endoscopic management of peptic ulcer bleeding. Drs Eric Tjwa, I. Lisanne Holster, and Ernst Kuipers from the Erasmus Medical Center University Hospital, Rotterdam, The Netherlands, review the endoscopic management of all other causes of acute nonvariceal upper GI bleeding, and in addition, Drs Louis Wong Kee Song and Michael Levy from the Mayo Clinic, Rochester, Minnesota discuss emerging endoscopic hemostasis treatments, such as topical sprays and over-the-scope clipping devices. Although endoscopic hemostasis is very highly effective, there are unfortunately cases where bleeding is unable to be controlled or when significant rebleeding occurs that is not amenable to endoscopic therapy. Therefore, I have included two articles that provide insight into the question...what if endoscopic hemostasis fails? The first article, written by Drs Philip Wai Yan Chiu and James Yun Wong Lau, from Prince of Wales Hospital, The Chinese University of Hong Kong, focuses on tried and true surgical treatment options. The second article, by Dr Sujal Nanavati, University of California at San Francisco, Department of Radiology and Biomedical Imaging, addresses the alternative treatment strategy of angiographic embolization, which has now emerged as the often preferred salvage treatment strategy.

The Guest Editor, Dr. Robert J. Shulman, and Consulting Editor, Dr. Alan Buchman, have created a thorough review of the current clinical updates on treating children with gastrointestinal disorders and diseases. Expert authors have submitted review articles on the following topics: Update on Diet Management of Functional GI Disorders; Brain-Gut Axis: Clinical Implications; Pancreatitis: Molecular Mechanisms and Management; Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us; GI Development: Implications for Management of the Preterm and Term Infant; Infectious Diarrhea: New and Emerging Issues; New Insights into the Pathogenesis and Treatment of Malnutrition; Infantile Colic: New Insights into an Old Problem; Constipation: Beyond the Old Paradigms; Integration of Biomedical and Psychosocial Treatments in Functional GI Disorders; GI Neuropathies: New Insights and Emerging Therapies; Food Sensitivities: Fact versus Fiction; IBD in Children: A Focus on Quality Improvement and Pediatric Focused Care; Molecular Advances in the Understanding of Pediatric Cholestasis; Assessment and Treatment of Nonadherence in Transplant Recipients; and Update on Fatty Liver Disease in Children. Readers will come away with the current updates they need to diagnose and treat pediatric patients and improve outcomes.

Dr. Alan Buchman, Consulting Editor, selected world renown experts on celiac disease, Dr. Green and Dr. Lebwohl, to update the topic for gastroenterology readers. They have secured expert authors from top institutions to contribute articles with high clinical utility on the diagnosis, treatment, and management of celiac disease. These clinical reviews are devoted to the following topics: Clinical features and diagnosis of celiac disease; The gluten-free diet; Histopathology of celiac disease; Epidemiology and risk factors for celiac disease; Enteroscopy and capsule endoscopy in celiac disease; Measuring symptoms and other outcomes in celiac disease; Celiac disease in Asia; The microbiome and celiac disease; Follow-up of celiac disease; Refractory celiac disease; Non-dietary therapies for celiac disease; and Non-Celiac gluten or wheat sensitivity. Readers will come away with the most current clinical information they need to inform clinical decisions to improve patient outcomes.